Review of the latest systemic treatments for chronic non-infectious uveitis

被引：3

作者：

Kheir, Valeria ^{[1
]}

Vaudaux, Jean ^{[1
]}

Guex-Crosier, Yan ^{[1
]}

机构：

[1] Univ Lausanne, FAA, Jules Gonin Eye Hosp, Lausanne, Switzerland

来源：

EXPERT REVIEW OF OPHTHALMOLOGY | 2016年 / 11卷 / 02期

关键词：

Systemic therapy; uveitis; corticosteroids; cyclosporine A; tacrolimus (FK506); sirolimus; rapamycine; azathioprine; methotrexate; mycophenolate mofetil; leflunomide; IFN-alpha; 2A; adalimumab; infliximab; etanercept; golimumab; daclizumab; certozilumab; tocilizumab; abatacept; rituximab; secukinumab; immunosuppressive drugs; anti-TNF therapies;

D O I：

10.1586/17469899.2016.1153425

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

In uveitis, initiating systemic therapy remains challenging. Over the last two decades, new systemic therapies have been developed and profoundly modified the clinicians' management practices with progress in knowledge of immune mechanisms regulating ocular inflammation. Keeping up to date with recent publications regarding systemic therapies in uveitis is key to managing severe uveitis in the best possible way. This article primarily focuses on literature published from 2005 to 2015 on systemic therapies in uveitis in adult patients; pediatric studies in uveitis may be cited to offer a better understanding of uveitis therapy. Rapid therapeutic decisions will influence the outcome and lower the burden of the disease.

引用

页码：111 / 133

页数：23

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