Review of the latest systemic treatments for chronic non-infectious uveitis

In uveitis, initiating systemic therapy remains challenging. Over the last two decades, new systemic therapies have been developed and profoundly modified the clinicians' management practices with progress in knowledge of immune mechanisms regulating ocular inflammation. Keeping up to date with recent publications regarding systemic therapies in uveitis is key to managing severe uveitis in the best possible way. This article primarily focuses on literature published from 2005 to 2015 on systemic therapies in uveitis in adult patients; pediatric studies in uveitis may be cited to offer a better understanding of uveitis therapy. Rapid therapeutic decisions will influence the outcome and lower the burden of the disease.