Clinical Presentation and Outcomes of Middle East Respiratory Syndrome in the Republic of Korea

被引：108

作者：

Choi, Won Suk ^{[1
]}

Kang, Cheol-In ^{[2
]}

Kim, Yonjae ^{[3
]}

Choi, Jae-Phil ^{[4
]}

Joh, Joon Sung ^{[5
]}

Shin, Hyoung-Shik ^{[3
]}

Kim, Gayeon ^{[3
]}

Peck, Kyong Ran ^{[2
]}

Chung, Doo Ryeon ^{[2
]}

Kim, Hye Ok ^{[4
]}

Song, Sook Hee ^{[4
]}

Kim, Yang Ree ^{[6
]}

Sohn, Kyung Mok ^{[7
]}

Jung, Younghee ^{[8
]}

Bang, Ji Hwan ^{[9
]}

Kim, Nam Joong ^{[9
]}

Lee, Kkot Sil ^{[10
]}

Jeong, Hye Won ^{[11
]}

Rhee, Ji-Young ^{[12
]}

Kim, Eu Suk ^{[13
]}

Woo, Heungjeong ^{[14
]}

Oh, Won Sup

Huh, Kyungmin ^{[15
,16
]}

Lee, Young Hyun ^{[17
]}

Song, Joon Young ^{[1
]}

Lee, Jacob ^{[14
]}

Lee, Chang-Seop ^{[18
,19
]}

Kim, Baek-Nam ^{[20
]}

Choi, Young Hwa ^{[21
]}

Jeong, Su Jin ^{[22
]}

Lee, Jin-Soo ^{[23
]}

Yoon, Ji Hyun ^{[24
]}

Wi, Yu Mi ^{[25
]}

Joung, Mi Kyong ^{[26
]}

Park, Seong Yeon ^{[27
]}

Lee, Sun Hee ^{[28
]}

Jung, Sook-In ^{[29
]}

Kim, Shin-Woo ^{[30
]}

Lee, Jae Hoon ^{[31
]}

Lee, Hyuck ^{[32
]}

Ki, Hyun Kyun ^{[33
]}

Kim, Yeon-Sook ^{[7
]}

机构：

[1] Korea Univ, Coll Med, Dept Internal Med, Div Infect Dis, Seoul, South Korea

[2] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Infect Dis, Seoul, South Korea

[3] Natl Med Ctr, Ctr Infect Dis, Seoul, South Korea

[4] Seoul Med Ctr, Dept Internal Med, Seoul, South Korea

[5] Natl Med Ctr, Resp Ctr, Seoul, South Korea

[6] Catholic Univ Korea, Uijeongbu St Marys Hosp, Div Infect Dis, Dept Internal Med, Uijongbu, South Korea

[7] Chungnam Natl Univ, Sch Med, Dept Internal Med, Div Infect Dis, Daejon, South Korea

[8] Hallym Univ, Sacred Heart Hosp, Dept Internal Med, Anyang, South Korea

[9] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea

[10] Seonam Univ, Dept Internal Med, Div Infect Dis, Myongji Hosp, Goyang, South Korea

[11] Chungbuk Natl Univ, Dept Internal Med, Coll Med, Cheongju, South Korea

[12] Dankook Univ, Coll Med, Dept Internal Med, Cheonan, South Korea

[13] Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Songnam, South Korea

[14] Hallym Univ, Coll Med, Dept Internal Med, Chunchon, South Korea

[15] Armed Forces Capital Hosp, Div Infect Dis, Songnam, South Korea

[16] Armed Forces Capital Hosp, Off Infect Control, Songnam, South Korea

[17] Dongguk Univ, Coll Med, Dept Internal Med, Gyeongju, South Korea

[18] Chonbuk Natl Univ, Sch Med, Dept Internal Med, Seoul, South Korea

[19] Chonbuk Natl Univ Hosp, Res Inst Clin Med, Seoul, South Korea

[20] Inje Univ, Sanggye Paik Hosp, Dept Internal Med, Seoul, South Korea

[21] Ajou Univ, Sch Med, Dept Internal Med, Suwon, South Korea

[22] Yonsei Univ, Coll Med, Dept Internal Med, Gangnam Severance Hosp, Seoul, South Korea

[23] Inha Univ, Coll Med, Dept Internal Med, Div Infect Dis, Inchon, South Korea

[24] Eulji Univ, Sch Med, Dept Internal Med, Daejeon, South Korea

[25] Samsung Changwon Hosp, Dept Internal Med, Chang Won, South Korea

[26] Busan Med Ctr, Dept Internal Med, Div Infect Dis, Busan, South Korea

[27] Dongguk Univ, Ilsan Hosp, Dept Internal Med, Div Infect Dis, Goyang, South Korea

[28] Pusan Natl Univ, Sch Med, Dept Internal Med, Busan, South Korea

[29] Chonnom Natl Univ, Sch Med, Dept Infect Dis, Gwangju, South Korea

[30] Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea

[31] Wonkwang Univ, Coll Med, Dept Internal Med, Iksan, South Korea

[32] Dong A Univ, Coll Med, Dept Internal Med, Busan, South Korea

[33] Konkuk Univ Hosp, Div Infect Dis, Seoul, South Korea

来源：

INFECTION AND CHEMOTHERAPY | 2016年 / 48卷 / 02期

关键词：

Middle East respiratory syn-drome; Republic of Korea;

D O I：

10.3947/ic.2016.48.2.118

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background: From May to July 2015, the Republic of Korea experienced the largest outbreak of Middle East respiratory syndrome (MERS) outside the Arabian Peninsula. A total of 186 patients, including 36 deaths, had been diagnosed with MERS-coronavirus (MERS-CoV) infection as of September 30th, 2015. Materials and Methods: We obtained information of patients who were confirmed to have MERS-CoV infection. MERS-CoV infection was diagnosed using real-time reverse-transcriptase polymerase chain reaction assay. Results: The median age of the patients was 55 years (range, 16 to 86). A total of 55.4% of the patients had one or more coexisting medical conditions. The most common symptom was fever (95.2%). At admission, leukopenia (42.6%), thrombocytopenia (46.6%), and elevation of aspartate aminotransferase (42.7%) were observed. Pneumonia was detected in 68.3% of patients at admission and developed in 80.8% during the disease course. Antiviral agents were used for 74.7% of patients. Mechanical ventilation, extracorporeal membrane oxygenation, and convalescent serum were employed for 24.5%, 7.1%, and 3.8% of patients, respectively. Older age, presence of coexisting medical conditions including diabetes or chronic lung disease, presence of dyspnea, hypotension, and leukocytosis at admission, and the use of mechanical ventilation were revealed to be independent predictors of death. Conclusion: The clinical features of MERS-CoV infection in the Republic of Korea were similar to those of previous outbreaks in the Middle East. However, the overall mortality rate (20.4%) was lower than that in previous reports. Enhanced surveillance and active management of patients during the outbreak may have resulted in improved outcomes.

引用

页码：118 / 126

页数：9

共 13 条

[1] Multifacility Outbreak of Middle East Respiratory Syndrome in Taif, Saudi Arabia [J].

Assiri, Abdullah ;

Abedi, Glen R. ;

Bin Saeed, Abdulaziz A. ;

Abdalla, Mutwakil A. ;

al-Masry, Malak ;

Choudhry, Abdul Jamil ;

Lu, Xiaoyan ;

Erdman, Dean D. ;

Tatti, Kathleen ;

Binder, Alison M. ;

Rudd, Jessica ;

Tokars, Jerome ;

Miao, Congrong ;

Alarbash, Hussain ;

Nooh, Randa ;

Pallansch, Mark ;

Gerber, Susan I. ;

Watson, John T. .

EMERGING INFECTIOUS DISEASES, 2016, 22 (01) :32-40

[2] Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study [J].

Assiri, Abdullah ;

Al-Tawfiq, Jaffar A. ;

Al-Rabeeah, Abdullah A. ;

Al-Rabiah, Fahad A. ;

Al-Hajjar, Sami ;

Al-Barrak, Ali ;

Flemban, Hesham ;

Al-Nassir, Wafa N. ;

Balkhy, Hanan H. ;

Al-Hakeem, Rafat F. ;

Makhdoom, Hatem Q. ;

Zumla, Alimuddin I. ;

Memish, Ziad A. .

LANCET INFECTIOUS DISEASES, 2013, 13 (09) :752-761

[3] Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus [J].

Assiri, Abdullah ;

McGeer, Allison ;

Perl, Trish M. ;

Price, Connie S. ;

Al Rabeeah, Abdullah A. ;

Cummings, Derek A. T. ;

Alabdullatif, Zaki N. ;

Assad, Maher ;

Almulhim, Abdulmohsen ;

Makhdoom, Hatem ;

Madani, Hossam ;

Alhakeem, Rafat ;

Al-Tawfiq, Jaffar A. ;

Cotten, Matthew ;

Watson, Simon J. ;

Kellam, Paul ;

Zumla, Alimuddin I. ;

Memish, Ziad A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (05) :407-416

[4] Antiviral Treatment Guidelines for Middle East Respiratory Syndrome [J].

Chong, Yong Pil ;

Song, Joon Young ;

Bin Seo, Yu ;

Choi, Jae-Phil ;

Shin, Hyoung-Shik .

INFECTION AND CHEMOTHERAPY, 2015, 47 (03) :212-222

[5] Spread, Circulation, and Evolution of the Middle East Respiratory Syndrome Coronavirus [J].

Cotten, Matthew ;

Watson, Simon J. ;

Zumla, Alimuddin I. ;

Makhdoom, Hatem Q. ;

Palser, Anne L. ;

Ong, Swee Hoe ;

Al Rabeeah, Abdullah A. ;

Alhakeem, Rafat F. ;

Assiri, Abdullah ;

Al-Tawfiq, Jaffar A. ;

Albarrak, Ali ;

Barry, Mazin ;

Shibl, Atef ;

Alrabiah, Fahad A. ;

Hajjar, Sami ;

Balkhy, Hanan H. ;

Flemban, Hesham ;

Rambaut, Andrew ;

Kellam, Paul ;

Memish, Ziad A. .

MBIO, 2014, 5 (01)

[6]

Korea Centers for Disease Control and Prevention, 2015, Osong Public Health Res Perspect, V6, P269, DOI 10.1016/j.phrp.2015.08.006

[7]

Korea Centers for Disease Control and Prevention (KCDC), RESP GUID MIDDL E RE

[8] Family Cluster of Middle East Respiratory Syndrome Coronavirus Infections [J].

Memish, Ziad A. ;

Zumla, Alimuddin I. ;

Al-Hakeem, Rafat F. ;

Al-Rabeeah, Abdullah A. ;

Stephens, Gwen M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (26) :2487-2494

[9] 2014 MERS-CoV Outbreak in Jeddah - A Link to Health Care Facilities [J].

Oboho, Ikwo K. ;

Tomczyk, Sara M. ;

Al-Asmari, Ahmad M. ;

Banjar, Ayman A. ;

Al-Mugti, Hani ;

Aloraini, Muhannad S. ;

Alkhaldi, Khulud Z. ;

Almohammadi, Emad L. ;

Alraddadi, Basem M. ;

Gerber, Susan I. ;

Swerdlow, David L. ;

Watson, John T. ;

Madani, Tariq A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (09) :846-854

[10] Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study [J].

Omrani, Ali S. ;

Saad, Mustafa M. ;

Baig, Kamran ;

Bahloul, Abdelkarim ;

Abdul-Matin, Mohammed ;

Alaidaroos, Amal Y. ;

Almakhlafi, Ghaleb A. ;

Albarrak, Mohammed M. ;

Memish, Ziad A. ;

Albarrak, Ali M. .

LANCET INFECTIOUS DISEASES, 2014, 14 (11) :1090-1095

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