PATHOGENESIS OF A LOCAL GRAFT VERSUS HOST REACTION - IMMUNOGENICITY OF CIRCULATING HOST LEUKOCYTES

被引：154

作者：

ELKINS, WL

GUTTMANN, RD

机构：

[1] Peter Bent Brigham Hospital, Harvard Medical School, Boston

来源：

SCIENCE | 1968年 / 159卷 / 3820期

关键词：

D O I：

10.1126/science.159.3820.1250

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A local invasive-destructive reaction typical of that seen in allograft rejection occurs when Lewis rat spleen cells are inoculated under the capsule of Lewis kidney freshly grafted into F1 hybrid hosts. Thus the donor lymphoid cells can be immunogenically stimulated by circulating host leukocytes and the interaction of these two cell populations results in nonspecific damage to kidney parenchyma. The results indicate that passenger leukocytes in organ allografts may be important immunogenic agents.

引用

页码：1250 / &

共 20 条

[1]

BILLINGHAM R, 1956, P ROY SOC LONDON, V239, P44

[2] INTERACTION OF DONOR AND HOST LYMPHOID CELLS IN PATHOGENESIS OF RENAL CORTICAL DESTRUCTION INDUCED BY A LOCAL GRAFT VERSUS HOST REACTION [J].