Phytochemical Analysis and Anticancer Activity of Seaweed Gracilaria verrucosa against Colorectal HCT-116 Cells

被引：5
|
作者：
Kurniasari, Kartika Dwi [1 ]
Arsianti, Ade [2 ,3 ]
Aziza, Yully Astika Nugrahayning [1 ]
Mandasari, Baiq Kirana Dyahningrum [1 ]
Masita, Riathul [1 ]
Zulfa, Futihati Ruhama [1 ]
Dem, Micheylla Kusumaning [1 ]
Zagloel, Cut Raisya Zahira [1 ]
Azizah, Norma Nur [3 ]
Putrianingsih, Rista [2 ]
机构：
[1] Univ Indonesia, Fac Med, Depok, Indonesia
[2] Univ Indonesia, Dept Med Chem, Fac Med, Depok, Indonesia
[3] Univ Indonesia, Fac Med, IMERI, Drug Dev Res Cluster, Jalan Salemba Raya 6, Jakarta 10430, Indonesia
来源：
ORIENTAL JOURNAL OF CHEMISTRY | 2018年 / 34卷 / 03期
关键词：
Phytochemistry; Gracillaria verrucosa; Anticancer activity; Colorectal HCT-116 cells;
D O I：
10.13005/ojc/340308
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this research, we develop Indonesia marine resource of seaweed Gracilaria verrucosa as an anti-colorectal cancer agent. Seaweed Gracilaria verrucosa which was collected from east Lombok beach, Nusa Tenggara Beret, Indonesia, were extracted into four different organic solvents, that is n-hexane, ethylacetate, chloroform and ethanol.The extracts were analyzed by Phytochemical test and Thin Layer Chromatography (TLC). Subsequently, anticancer activity of n-hexane, ethyl acetate, chloroform and ethanol extracts of Gracilaria verrucosa were evaluated against colorectal HCT-116 cells by MTT cell proliferation assay. Based on Phytochemical analysis, the extracts of Gracilaria verrucosa containing secondary metabolite of saponin, while TLC analysis indicated that the extracts were composed by five chemical compounds. Among four concentrated extracts of Gracilaria verrucosa, ethanolic extract showed the strongest anticancer activity against colorectal HCT-116 cells with IC50 of 43.9 mu g/mL.Ethanolic extract of seaweed Gracilaria verrucosa is potential to be further developed as a promising anti-colorectal cancer agents.
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收藏
页码：1257 / 1262
页数：6
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