PERSISTENCE OF HYPERINSULINEMIA IN POLYCYSTIC-OVARY-SYNDROME AFTER OVARIAN SUPPRESSION BY GONADOTROPIN-RELEASING-HORMONE AGONIST

被引:30
作者
DALE, PO
TANBO, T
DJOSELAND, O
JERVELL, J
ABYHOLM, T
机构
[1] UNIV OSLO,NAT HOSP,DEPT GYNECOL & OBSTET,OSLO 3,NORWAY
[2] UNIV OSLO,NAT HOSP,DEPT MED,OSLO 3,NORWAY
来源
ACTA ENDOCRINOLOGICA | 1992年 / 126卷 / 02期
关键词
D O I
10.1530/acta.0.1260132
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To investigate the effect of long-term androgen suppression on insulin sensitivity, obese and non-obese women with the polycystic ovary syndrome and obese and non-obese ovulatory women were given an oral glucose tolerance test before and after treatment with a gonadotropin-releasing hormone agonist. The women with polycystic ovary syndrome showed higher basal luteinizing hormone and androgen levels than the ovulatory women. All women with the polycystic ovary syndrome responded non-diabetically to the glucose tolerance test. However, compared with controls, the obese women with the polycystic ovary syndrome showed a hyperinsulinemic response to the glucose tolerance test, indicating insulin resistance. During the 3-h glucose tolerance test there was no concomitant change in androgen levels in the hyperinsulinemic women with the polycystic ovary syndrome. The insulin response to an oral glucose tolerance test remained unchanged in all women, although a hypogonadotropic hypogonadal state was maintained for several weeks. This study therefore suggests that endogenous androgens do not play a role in sustaining insulin resistance in women with the polycystic ovary syndrome.
引用
收藏
页码:132 / 136
页数:5
相关论文
共 28 条
[1]   PREVALENCE OF POLYCYSTIC OVARIES IN WOMEN WITH ANOVULATION AND IDIOPATHIC HIRSUTISM [J].
ADAMS, J ;
POLSON, DW ;
FRANKS, S .
BRITISH MEDICAL JOURNAL, 1986, 293 (6543) :355-359
[2]   INSULIN STIMULATES ANDROGEN ACCUMULATION IN INCUBATIONS OF OVARIAN STROMA OBTAINED FROM WOMEN WITH HYPERANDROGENISM [J].
BARBIERI, RL ;
MAKRIS, A ;
RANDALL, RW ;
DANIELS, G ;
KISTNER, RW ;
RYAN, KJ .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1986, 62 (05) :904-910
[3]  
BARBIERI RL, 1988, FERTIL STERIL, V50, P197
[4]   CORRELATION OF HYPERANDROGENISM WITH HYPERINSULINISM IN POLYCYSTIC OVARIAN DISEASE [J].
BURGHEN, GA ;
GIVENS, JR ;
KITABCHI, AE .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1980, 50 (01) :113-116
[5]   INSULIN RESISTANCE IN NON-OBESE PATIENTS WITH POLYCYSTIC OVARIAN DISEASE [J].
CHANG, RJ ;
NAKAMURA, RM ;
JUDD, HL ;
KAPLAN, SA .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1983, 57 (02) :356-359
[6]   INSULIN RESISTANCE AND DIMINISHED GLUCOSE-TOLERANCE IN POWERLIFTERS INGESTING ANABOLIC-STEROIDS [J].
COHEN, JC ;
HICKMAN, R .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1987, 64 (05) :960-963
[7]   GNRH-AGONIST THERAPY IN WOMEN WITH THE POLYCYSTIC OVARIAN SYNDROME - EFFECTS ON OVARIAN VOLUME AND ON GONADOTROPIN AND SEX STEROID-LEVELS [J].
DALE, PO ;
TANBO, T ;
HAUG, E ;
ABYHOLM, T .
GYNECOLOGICAL ENDOCRINOLOGY, 1989, 3 (04) :309-315
[8]   INSULIN RESISTANCE AND HYPERINSULINEMIA INDUCE HYPERANDROGENISM IN A YOUNG TYPE-B INSULIN-RESISTANT FEMALE [J].
DECLUE, TJ ;
SHAH, SC ;
MARCHESE, M ;
MALONE, JI .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1991, 72 (06) :1308-1311
[9]   PROFOUND PERIPHERAL INSULIN RESISTANCE, INDEPENDENT OF OBESITY, IN POLYCYSTIC OVARY SYNDROME [J].
DUNAIF, A ;
SEGAL, KR ;
FUTTERWEIT, W ;
DOBRJANSKY, A .
DIABETES, 1989, 38 (09) :1165-1174
[10]   SUPPRESSION OF HYPERANDROGENISM DOES NOT IMPROVE PERIPHERAL OR HEPATIC INSULIN RESISTANCE IN THE POLYCYSTIC OVARY SYNDROME [J].
DUNAIF, A ;
GREEN, G ;
FUTTERWEIT, W ;
DOBRJANSKY, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1990, 70 (03) :699-704