Hypertension and angiotensin system inhibitors in patients with metastatic renal cell carcinoma

被引：19

作者：

Derosa, Lisa ^{[1
]}

Izzedine, Hassane ^{[2
]}

Albiges, Laurence ^{[1
]}

Escudier, Bernard ^{[1
]}

机构：

[1] Univ Paris Saclay, Gustave Roussy Canc Ctr, 114 Rue Edouard Vaillant, F-94805 Villejuif, France

[2] Hop La Pitie Salpetriere, Dept Nephrol & Pathol, Paris, France

来源：

ONCOLOGY REVIEWS | 2016年 / 10卷 / 02期

关键词：

Hypertension; angiotensin system inhibitors; renal cell carcinoma; renin-angiotensin system;

D O I：

10.4081/oncol.2016.298

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Arterial hypertension (HTN) is a class effect of anti vascular endothelial growth factor (VEGF) therapies, including the monoclonal antibody bevacizumab. Data are conflicting regarding the role of the renin-angiotensin system on angiogenesis and recent data suggest that the use of angiotensin system inhibitors (ASIs; angiotensin receptor blockers or angiotensin-converting enzyme inhibitors) is associated with improved survival in metastatic renal cell carcinoma (mRCC), particularly when used with VEGF targeted therapies. The aim of this review is to discuss the available treatment options for mRCC and associated incidence of hypertension as well as summarize the known data about ASIs use and mRCC. Additionally, given that the optimal management of HTN remains unclear, we will focus on prevention strategies and propose potential therapeutic approaches.

引用

页码：54 / 59

页数：6

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