Cancer Stem Cell and Stromal Microenvironment

被引：3

作者：

Li, Li ^{[1
]}

Cole, John ^{[2
,3
]}

Margolin, David A. ^{[3
]}

机构：

[1] Inst Translat Res, Lab Translat Canc Res, New Orleans, LA USA

[2] Ochsner Clin Sch, Dept Hematol & Oncol, New Orleans, LA USA

[3] Univ Queensland, Sch Med, Brisbane, Qld 4072, Australia

来源：

OCHSNER JOURNAL | 2013年 / 13卷 / 01期

关键词：

Cancer metastasis; cancer stem cells; drug resistance; stromal cells; tumor microenvironment;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Chemotherapeutic resistance and local recurrence or distant organ metastasis are the major causes of cancer mortality. Conventional cancer treatments do not consistently prevent cancer recurrence. Methods: We illustrate the key roles that cancer stem cells and the tumor microenvironment-particularly the lymph node stromal microenvironment-play in tumor drug resistance, metastasis, and recurrence in 2 representative cancers: colorectal cancer and follicular lymphoma. Conclusion: We believe that combination treatment with chemotherapeutic agents in conjunction with targeted therapies, such as stromal/cancer stem cell signaling-targeted therapy, may effectively minimize cancer recurrence.

引用

页码：109 / 118

页数：10

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