THERAPEUTIC TRIAL OF INTRACISTERNAL HUMAN TETANUS IMMUNOGLOBULIN IN CLINICAL TETANUS

被引：20

作者：

VAKIL, BJ

ARMITAGE, P

CLIFFORD, RE

LAURENCE, DR

机构：

[1] UNIV OXFORD,OXFORD OX1 2JZ,ENGLAND

[2] UNIV COLL HOSP LONDON,SCH MED,LONDON WC1E 6JJ,ENGLAND

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1979年 / 73卷 / 05期

关键词：

D O I：

10.1016/0035-9203(79)90058-0

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

A trial has been conducted of the efficacy of human tetanus immunoglobulin (250 I U) administered intrathecally (intracisternally) in addition to standard treatment (equine antitoxin intravenously, penicillin, anticonvulsants). The trial was analysed sequentially and was stopped after 120 patients when there was no longer any chance of achieving a statistically significant difference in favour of intrathecal administration. The sequential plan was modified during the trial. A prognostic correlation was found between onset of the first symptom and admission to hospital. © 1979 by The University of Chicago.

引用

页码：579 / 583

页数：5