NOVEL BINDING MODE OF HIGHLY POTENT HIV-PROTEINASE INHIBITORS INCORPORATING THE (R)-HYDROXYETHYLAMINE ISOSTERE

被引：191

作者：

KROHN, A ^{[1
]}

REDSHAW, S ^{[1
]}

RITCHIE, JC ^{[1
]}

GRAVES, BJ ^{[1
]}

HATADA, MH ^{[1
]}

机构：

[1] HOFFMANN LA ROCHE INC,ROCHE RES CTR,NUTLEY,NJ 07110

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 34卷 / 11期

关键词：

D O I：

10.1021/jm00115a028

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：3340 / 3342

页数：3

共 15 条

[1]

ARROWSMITH RJ, 1989, SPEC PUBL R SOC CHEM, V78, P112

[2] ASSAY OF HIV-1 PROTEINASE - A COLORIMETRIC METHOD USING SMALL PEPTIDE-SUBSTRATES [J].

BROADHURST, AV ;

ROBERTS, NA ;

RITCHIE, AJ ;

HANDA, BK ;

KAY, C .

ANALYTICAL BIOCHEMISTRY, 1991, 193 (02) :280-286

[3]

Cooper J.B., 1988, TOPICS MED CHEM, P308

[4] DESIGN, ACTIVITY, AND 2.8 A CRYSTAL-STRUCTURE OF A C2 SYMMETRICAL INHIBITOR COMPLEXED TO HIV-1 PROTEASE [J].

ERICKSON, J ;

NEIDHART, DJ ;

VANDRIE, J ;

KEMPF, DJ ;

WANG, XC ;

NORBECK, DW ;

PLATTNER, JJ ;

RITTENHOUSE, JW ;

TURON, M ;

WIDEBURG, N ;

KOHLBRENNER, WE ;

SIMMER, R ;

HELFRICH, R ;

PAUL, DA ;

KNIGGE, M .

SCIENCE, 1990, 249 (4968) :527-533

[5]

FITZGERALD PMD, 1990, J BIOL CHEM, V265, P14209

[6]

GRAVES BJ, IN PRESS

[7] STRUCTURE AT 2.5-A RESOLUTION OF CHEMICALLY SYNTHESIZED HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASE COMPLEXED WITH A HYDROXYETHYLENE-BASED INHIBITOR [J].

JASKOLSKI, M ;

TOMASSELLI, AG ;

SAWYER, TK ;

STAPLES, DG ;

HEINRIKSON, RL ;

SCHNEIDER, J ;

KENT, SBH ;

WLODAWER, A .

BIOCHEMISTRY, 1991, 30 (06) :1600-1609

[8] STRUCTURE OF COMPLEX OF SYNTHETIC HIV-1 PROTEASE WITH A SUBSTRATE-BASED INHIBITOR AT 2.3-A RESOLUTION [J].

MILLER, M ;

SCHNEIDER, J ;

SATHYANARAYANA, BK ;

TOTH, MV ;

MARSHALL, GR ;

CLAWSON, L ;

SELK, L ;

KENT, SBH ;

WLODAWER, A .

SCIENCE, 1989, 246 (4934) :1149-1152

[9]

NATARAJAN S, 1988, PEPTIDES CHEM BIOL, P131

[10] HYDROXYETHYLAMINE ANALOGS OF THE P17/P24 SUBSTRATE CLEAVAGE SITE ARE TIGHT-BINDING INHIBITORS OF HIV PROTEASE [J].

RICH, DH ;

GREEN, J ;

TOTH, MV ;

MARSHALL, GR ;

KENT, SBH .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (05) :1285-1288

← 1 2 →