TRIAL OF 5-FLUOROURACIL AND CORYNEBACTERIUM-PARVUM IN ADVANCED COLORECTAL-CARCINOMA

被引：1

作者：

GOUGH, IR

CLUNIE, GJA

BOLTON, PM

DURY, M

BURNETT, W

机构：

[1] Department of Surgery, University of Queensland, Brisbane, 4029, Clinical Sciences Building, Royal Brisbane Hospital

来源：

DISEASES OF THE COLON & RECTUM | 1979年 / 22卷 / 04期

关键词：

D O I：

10.1007/BF02586879

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

This study has confirmed that patients who have advanced colorectal carcinoma have impaired responsiveness to delayed-hypersensitivity skin testing, and also have elevated levels of serum IgM. Serial observations of delayed-hypersensitivity skin tests, total lymphocyte counts, T-lymphocyte counts, B-lymphocyte counts, and serum immunoglobulin levels failed to reveal any consistent pattern of responses in patients treatment with either chemotherapy alone or chemoimmunotherapy. In 33 patients chosen at random to receive either 5-FU alone or 5-FU in combination with intramuscularly administered C. parvum, there was no evidence of objective response or influence on survival. Intramuscularly administered C. parvum, in the dose and schedule used, produced no evident immunologic or therapeutic effect. © 1979 American Society of Colon and Rectal Surgeons.

引用

页码：223 / 227

页数：5

共 50 条

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