THE CATALYTIC ROLE OF THE ACTIVE-SITE ASPARTIC-ACID IN SERINE PROTEASES

被引:319
作者
CRAIK, CS
ROCZNIAK, S
LARGMAN, C
RUTTER, WJ
机构
[1] UNIV CALIF SAN FRANCISCO,DEPT BIOCHEM & BIOPHYS,SAN FRANCISCO,CA 94143
[2] UNIV CALIF SAN FRANCISCO,HORMONE RES INST,SAN FRANCISCO,CA 94143
关键词
D O I
10.1126/science.3303334
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:909 / 913
页数:5
相关论文
共 40 条
[1]   N-15 NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY - STATE OF HISTIDINE IN CATALYTIC TRIAD OF ALPHA-LYTIC PROTEASE - IMPLICATIONS FOR CHARGE-RELAY MECHANISM OF PEPTIDE-BOND CLEAVAGE BY SERINE PROTEASES [J].
BACHOVCHIN, WW ;
ROBERTS, JD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1978, 100 (26) :8041-8047
[2]   CORRELATION OF PH (PD) DEPENDENCE + STEPWISE MECHANISM OF ALPHA-CHYMOTRYPSIN-CATALYZED REACTIONS [J].
BENDER, ML ;
CLEMENT, GE ;
HECK, HD ;
KEZDY, FJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (18) :3680-&
[3]   STRUCTURE OF CRYSTALLINE ALPHA-CHYMOTRYPSIN .5. ATOMIC STRUCTURE OF TOSYL-ALPHA-CHYMOTRYPSIN AT 2 A RESOLUTION [J].
BIRKTOFT, JJ ;
BLOW, DM .
JOURNAL OF MOLECULAR BIOLOGY, 1972, 68 (02) :187-&
[4]   ROLE OF A BURIED ACID GROUP IN MECHANISM OF ACTION OF CHYMOTRYPSIN [J].
BLOW, DM ;
BIRKTOFT, JJ ;
HARTLEY, BS .
NATURE, 1969, 221 (5178) :337-&
[5]   REFINED 2 A X-RAY CRYSTAL-STRUCTURE OF PORCINE PANCREATIC KALLIKREIN-A, A SPECIFIC TRYPSIN-LIKE SERINE PROTEINASE - CRYSTALLIZATION, STRUCTURE DETERMINATION, CRYSTALLOGRAPHIC REFINEMENT, STRUCTURE AND ITS COMPARISON WITH BOVINE TRYPSIN [J].
BODE, W ;
CHEN, ZG ;
BARTELS, K ;
KUTZBACH, C ;
SCHMIDTKASTNER, G ;
BARTUNIK, H .
JOURNAL OF MOLECULAR BIOLOGY, 1983, 164 (02) :237-282
[6]   MOLECULAR-STRUCTURE OF THE ALPHA-LYTIC PROTEASE FROM MYXOBACTER-495 AT 2-8-A RESOLUTION [J].
BRAYER, GD ;
DELBAERE, LTJ ;
JAMES, MNG .
JOURNAL OF MOLECULAR BIOLOGY, 1979, 131 (04) :743-775
[7]   MOLECULAR-STRUCTURE OF CRYSTALLINE STREPTOMYCES-GRISEUS PROTEASE-A AT 2.8-A RESOLUTION .2. MOLECULAR-CONFORMATION, COMPARISON WITH ALPHA-CHYMOTRYPSIN AND ACTIVE-SITE GEOMETRY [J].
BRAYER, GD ;
DELBAERE, LTJ ;
JAMES, MNG .
JOURNAL OF MOLECULAR BIOLOGY, 1978, 124 (01) :261-283
[8]   4.5 A RESOLUTION STRUCTURE OF A BACTERIAL SERINE PROTEASE FROM STREPTOMYCES-GRISEUS [J].
CODDING, PW ;
DELBAERE, LT ;
HAYAKAWA, K ;
HUTCHEON, WL ;
JAMES, MNG ;
JURASEK, L .
CANADIAN JOURNAL OF BIOCHEMISTRY, 1974, 52 (03) :208-220
[9]   REDESIGNING TRYPSIN - ALTERATION OF SUBSTRATE-SPECIFICITY [J].
CRAIK, CS ;
LARGMAN, C ;
FLETCHER, T ;
ROCZNIAK, S ;
BARR, PJ ;
FLETTERICK, R ;
RUTTER, WJ .
SCIENCE, 1985, 228 (4697) :291-297
[10]  
CRAIK CS, UNPUB