MOLECULAR-CLONING OF A MOUSE COUNTERPART FOR HUMAN TGF-BETA TYPE-I RECEPTOR

被引：26
作者：
TOMODA, T
KUDOH, T
NOMA, T
NAKAZAWA, A
MURAMATSU, M
ARAI, K
机构：
[1] UNIV TOKYO,INST MED SCI,DEPT MOLEC & DEV BIOL,MINATO KU,TOKYO,TOKYO 108,JAPAN
[2] YAMAGUCHI UNIV,SCH MED,DEPT BIOCHEM 2,YAMAGUCHI 753,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 198卷 / 03期
关键词：
D O I：
10.1006/bbrc.1994.1150
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
TGF-β is a multifunctional polypeptide which is involved in the regulation of cell growth, differentiation, and immunomodulation. Its signaling receptors on the cell surface are postulated to be the type I (TGF βRI) and type II receptors (TGF βRII). Previously, TGF βRII has been cloned and was found to be a receptor type serine/threonine kinase (RSK). In an attempt to isolate novel RSKs expressed in mouse ES cells, we obtained a clone designated as ESK2, which was very closely related to human TGF βRI. The amino acid sequence of the intracellular domain is completely identical and the transmembrane domain is identical except for one residue. The extracellular domain is 90% homologous with a deletion and an insertion of four amino acid residues. ESK2 also binds to TGF-β in the presence of TGF βRII, indicating that ESK2 is the mouse counterpart for human TGF βRI. © 1994 Academic Press, Inc.
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页码：1054 / 1062
页数：9
相关论文
共 27 条
[1]   NOVEL ACTIVIN RECEPTORS - DISTINCT GENES AND ALTERNATIVE MESSENGER-RNA SPLICING GENERATE A REPERTOIRE OF SERINE THREONINE KINASE RECEPTORS [J].
ATTISANO, L ;
WRANA, JL ;
CHEIFETZ, S ;
MASSAGUE, J .
CELL, 1992, 68 (01) :97-108
[2]   IDENTIFICATION OF HUMAN ACTIVIN AND TGF-BETA TYPE-I RECEPTORS THAT FORM HETEROMERIC KINASE COMPLEXES WITH TYPE-II RECEPTORS [J].
ATTISANO, L ;
CARCAMO, J ;
VENTURA, F ;
WEIS, FMB ;
MASSAGUE, J ;
WRANA, JL .
CELL, 1993, 75 (04) :671-680
[3]  
AZUMA S, 1991, Japanese Journal of Animal Reproduction, V37, P37
[4]   CONTROL OF CELL PATTERN IN THE NEURAL-TUBE - REGULATION OF CELL-DIFFERENTIATION BY DORSALIN-1, A NOVEL TGF-BETA FAMILY MEMBER [J].
BASLER, K ;
EDLUND, T ;
JESSELL, TM ;
YAMADA, T .
CELL, 1993, 73 (04) :687-702
[5]   ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].
CHIRGWIN, JM ;
PRZYBYLA, AE ;
MACDONALD, RJ ;
RUTTER, WJ .
BIOCHEMISTRY, 1979, 18 (24) :5294-5299
[6]   DETERMINATION OF TYPE-I RECEPTOR SPECIFICITY BY THE TYPE-II RECEPTORS FOR TGF-BETA OR ACTIVIN [J].
EBNER, R ;
CHEN, RH ;
LAWLER, S ;
ZIONCHECK, T ;
DERYNCK, R .
SCIENCE, 1993, 262 (5135) :900-902
[7]   CLONING OF A TYPE-I TGF-BETA RECEPTOR AND ITS EFFECT OF TGF-BETA BINDING TO THE TYPE-II RECEPTOR [J].
EBNER, R ;
CHEN, RH ;
SHUM, L ;
LAWLER, S ;
ZIONCHECK, TF ;
LEE, A ;
LOPEZ, AR ;
DERYNCK, R .
SCIENCE, 1993, 260 (5112) :1344-1348
[8]   THE DAF-4 GENE ENCODES A BONE MORPHOGENETIC PROTEIN-RECEPTOR CONTROLLING C-ELEGANS DAUER LARVA DEVELOPMENT [J].
ESTEVEZ, M ;
ATTISANO, L ;
WRANA, JL ;
ALBERT, PS ;
MASSAGUE, J ;
RIDDLE, DL .
NATURE, 1993, 365 (6447) :644-649
[9]   CLONING OF A TGF-BETA TYPE-I RECEPTOR THAT FORMS A HETEROMERIC COMPLEX WITH THE TGF-BETA TYPE-II RECEPTOR [J].
FRANZEN, P ;
TENDIJKE, P ;
ICHIJO, H ;
YAMASHITA, H ;
SCHULZ, P ;
HELDIN, CH ;
MIYAZONO, K .
CELL, 1993, 75 (04) :681-692
[10]   PURIFICATION AND INITIAL CHARACTERIZATION OF A TYPE-BETA TRANSFORMING GROWTH-FACTOR FROM HUMAN-PLACENTA [J].
FROLIK, CA ;
DART, LL ;
MEYERS, CA ;
SMITH, DM ;
SPORN, MB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (12) :3676-3680
123