BIODEGRADABLE POLY(DL-LACTIC ACID) FORMULATIONS IN A CALCITONIN DELIVERY SYSTEM

被引：21

作者：

ASANO, M

YOSHIDA, M

OMICHI, H

MASHIMO, T

OKABE, K

YUASA, H

YAMANAKA, H

MORIMOTO, S

SAKAKIBARA, H

机构：

[1] JAPAN ATOM ENERGY RES INST,TAKASAKI RADIAT CHEM RES ESTABLISHMENT,DEPT MAT DEV,TAKASAKI,GUNMA 37012,JAPAN

[2] GUNMA UNIV,SCH MED,DEPT UROL,MAEBASHI,GUNMA 371,JAPAN

[3] TOYO JOZO CO LTD,RES LABS,OHITO,SHIZUOKA 41023,JAPAN

来源：

BIOMATERIALS | 1993年 / 14卷 / 10期

关键词：

BIODEGRADATION; DL-LACTIC ACID; DRUG DELIVERY; CALCITONIN ANALOG;

D O I：

10.1016/0142-9612(93)90047-6

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A synthetic analogue of eel calcitonin, [Asu1,7]-ECT, was incorporated into biodegradable poly(DL-lactic acids) with number-average molecular weights (M(n)) of 1400-4400 by the melt-pressing technique. The in vitro release of drug from a parabolically degradable poly(DL-lactic acid) with M(n) = 1400 showed an initial burst release and completed the release in 3 d from the start of the test. The drug release from a M(n) = 4400 polymer with an S-type degradation pattern was kept at 14 +/- 5 units/d for an experimental period of 24 d.

引用

页码：797 / 799

页数：3

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