HTLV-I TRANS-ACTIVATOR PROTEIN, TAX, IS A TRANS-REPRESSOR OF THE HUMAN BETA-POLYMERASE GENE

被引：305

作者：

JEANG, KT ^{[1
]}

WIDEN, SG ^{[1
]}

SEMMES, OJ ^{[1
]}

WILSON, SH ^{[1
]}

机构：

[1] NCI,BIOCHEM LAB,BETHESDA,MD 20892

来源：

SCIENCE | 1990年 / 247卷 / 4946期

关键词：

D O I：

10.1126/science.2309119

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Human T cell leukemia virus type I (HTLV-I) is the etiological agent for adult T cell leukemia (ATL). The HTLV-I trans-activator protein Tax can activate the expression of its own long terminal repeat (LTR) and many cellular and viral genes. Tax down-regulated the expression of human β-polymerase (huβ-pol), a cellular enzyme involved in host cell DNA repair. This finding suggests a possible correlation between HTLV-I infection and host chromosomal damage, which is often seen in ATL cells.

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页码：1082 / 1084

页数：3

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