ACTION OF A NEW CHOLINERGIC AGONIST, ACLATONIUM NAPADISILATE, ON ISOLATED RAT PANCREATIC ACINI

被引：1

作者：

FUJII, M

OKABAYASHI, Y

NAKAMURA, T

TANI, S

FUJISAWA, T

OTSUKI, M

机构：

[1] Second Department of Internal Medicine, Kobe University School of Medicine, Kobe

来源：

PANCREAS | 1990年 / 5卷 / 04期

关键词：

Aclatonium napadisilate; Amylase release; Carbamylcholine; Isolated acini; Muscarinic receptor;

D O I：

10.1097/00006676-199007000-00009

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The effect of aclatonium napadisilate, a newly synthesized choline ester, on pancreatic exocrine function was compared with that of the muscarinic agonist carbamylcholine in isolated rat pancreatic acini. Both compounds increased amylase release and45Ca2+efflux in a dose-dependent fashion, and similarly decreased the binding of [N-methyl-3H]scopolamine to isolated rat pancreatic acini. While aclatonium napadisilate was 20-30 times less potent than carbamylcholine in stimulations of amylase release and45Ca2+efflux, the potency of aclatonium napadisilate in inhibiting [A7-methyl-3H]scopolamine binding was nearly the same as that of carbamylcholine. These results indicate that aclatonium napadisilate stimulates pancreatic exocrine secretion via muscarinic receptors and Ca2+mobilization, and its intrinsic activity is less than carbamylcholine in the isolated rat pancreatic acini. Since aclatonium napadisilate is known to increase motility and peristalsis of the gastrointestinal tract, stimulatory effects of aclatonium napadisilate, shown in the present study, on digestive enzyme secretion from the pancreas may provide additional benefit of aclatonium napadisilate in the treatment of various gastrointestinal disorders. © 1990 Raven Press Ltd., New York.

引用

页码：427 / 433

页数：7

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