DIETHYLSTILBESTROL INDUCES NEOPLASTIC TRANSFORMATION WITHOUT MEASURABLE GENE MUTATION AT 2 LOCI

被引：183
作者：
BARRETT, JC
WONG, A
MCLACHLAN, JA
机构：
[1] NIEHS, PULM FUNCT & TOXICOL LAB, ENVIRONM CARCINOGENESIS GRP, RES TRIANGLE PK, NC 27709 USA
[2] NIEHS, REPROD & DEV TOXICOL LAB, TRANSPLACENTAL TOXICOL GRP, RES TRIANGLE PK, NC 27709 USA
来源：
SCIENCE | 1981年 / 212卷 / 4501期
关键词：
D O I：
10.1126/science.6262919
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The frequency with which diethylstilbestrol induces neoplastic transformation and somatic mutation was measured concomitantly in Syrian hamster embryo cells. While diethylstilbestrol was as active as benzo[a]pyrene in inducing transformation, it failed to induce mutations at 2 conventionally studied loci. Diethylstilbestrol may transform cells in the absence of gene mutations.
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页码：1402 / 1404
页数：3
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