INTESTINAL-ABSORPTION OF INORGANIC MERCURY IN RAT

被引：14

作者：

PIOTROWSKI, JK ^{[1
]}

SZYMANSKA, JA ^{[1
]}

SKRZYPINSKAGAWRYSIAK, M ^{[1
]}

KOTELO, J ^{[1
]}

SPORNY, S ^{[1
]}

机构：

[1] MED ACAD LODZ,DEPT PATHOL,PL-90141 LODZ,POLAND

来源：

PHARMACOLOGY & TOXICOLOGY | 1992年 / 70卷 / 01期

关键词：

D O I：

10.1111/j.1600-0773.1992.tb00426.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hg-203-Mercuric chloride was administered intragastrically to female rats. The absorption rate evaluated for a broad range of doses was found constant for low and medium range, and higher for high doses. Mercury was determined in internal organs and intestines. The time-course of intestinal mercury indicated that a deposit formed initially in the mucosa was further absorbed into the circulation. No indication was found of a protection mechanism based on exfoliation of the mucosal deposits of metal.

引用

收藏

页码：53 / 55

页数：3

相关论文

共 15 条

[1] ORAL CADMIUM CHLORIDE INTOXICATION IN MICE - EFFECTS OF DOSE ON TISSUE-DAMAGE, INTESTINAL-ABSORPTION AND RELATIVE ORGAN DISTRIBUTION [J].

ANDERSEN, O ;

NIELSEN, JB ;

SVENDSEN, P .

TOXICOLOGY, 1988, 48 (03) :225-236

[2]

CHAYEN J, 1973, PRACTICAL HISTOCHEMI

[3]

CIKRT M, 1971, Internationales Archiv fuer Arbeitsmedizin, V28, P12, DOI 10.1007/BF00539726

[4] MECHANISMS OF ABSORPTION OF INORGANIC MERCURY FROM RAT SMALL-INTESTINE .3. COMPARATIVE ABSORPTION STUDIES OF INORGANIC MERCURIC COMPOUNDS INVITRO [J].

ENDO, T ;

NAKAYA, S ;

KIMURA, R .

PHARMACOLOGY & TOXICOLOGY, 1990, 66 (05) :347-353

[5] MECHANISMS OF ABSORPTION OF INORGANIC MERCURY FROM RAT SMALL-INTESTINE .2. COMPOSITE EFFECTS OF PH AND HALIDE-IONS ON TRANSPORT OF MERCURIC-CHLORIDE INTO ISOLATED BRUSH-BORDER MEMBRANE-VESICLES IN RATS [J].

ENDO, T ;

NAKAYA, S ;

KIMURA, R .

PHARMACOLOGY & TOXICOLOGY, 1988, 63 (05) :361-368

[6] MECHANISMS OF ABSORPTION OF INORGANIC MERCURY FROM RAT SMALL-INTESTINE .1. SOLVENT DRAG EFFECT ON ABSORPTION OF INORGANIC MERCURY [J].

ENDO, T ;

NAKAYA, S ;

KIMURA, R .

PHARMACOLOGY & TOXICOLOGY, 1988, 63 (01) :8-15

[7] GASTROINTESTINAL ABSORPTION OF INORGANIC MERCURIC COMPOUNDS INVIVO AND INSITU [J].

ENDO, T ;

NAKAYA, S ;

KIMURA, R ;

MURATA, T .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1984, 74 (02) :223-229

[8] DOSE DEPENDENCE OF GASTRO-INTESTINAL ABSORPTION AND BIOLOGICAL HALF-TIME OF CADMIUM IN MICE [J].

ENGSTROM, B ;

NORDBERG, GF .

TOXICOLOGY, 1979, 13 (03) :215-222

[9]

Friberg L, 1979, HDB TOXICOLOGY METAL

[10] AGE AND INTESTINAL RETENTION OF MERCURY AND CADMIUM IN RATS [J].

KOSTIAL, K ;

SIMONOVIC, I ;

RABAR, I ;

BLANUSA, M ;

LANDEKA, M .

ENVIRONMENTAL RESEARCH, 1983, 31 (01) :111-115