HIV-1 VARIANTS IN SOUTH AND SOUTH-EAST ASIA

被引:20
作者
TSUCHIE, H
SARASWATHY, TS
SINNIAH, M
VIJAYAMALAR, B
MANIAR, JK
MONZON, OT
SANTANA, RT
PALADIN, FJE
WASI, C
THONGCHAROEN, P
HOSSAIN, MM
YAMADA, O
KAGEYAMA, S
KITAMURA, T
KURIMURA, T
机构
[1] Res. Institute Microbial Diseases, Osaka University, Suita, Osaka 565
关键词
HIV-1; ASIA; ENV; GENETIC VARIATION; MOLECULAR PHYLOGENY;
D O I
10.1177/095646249500600211
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
HIV spread in South and South-East Asia is most alarming, and genetic variability of HIV-1 is an important consideration in vaccine development. In this study, we examined the third variable (V3) region of env gene of HIV-1 variants prevalent in Thailand, Malaysia, India, and the Philippines. By phylogenetic tree analyses, an HIV-1 variant from an injecting drug user (IDU) in Thailand belonged to subtype B, and HIV-1 variants from 2 IDUs in Malaysia were classified into 2 subtypes, B and E. One HIV-1 variant from a male homosexual in the Philippines belonged to subtype B. Out of 8 HIV-1 variants from sexually transmitted disease patients in India, 7 belonged to subtype C, and one to subtype A. Although the total number of individuals examined in this study was limited, 4 HIV-1 subtypes were found in South and South-East Asia and large international movements of HIV-1-infected individuals in this region could induce global dissemination of these HIV-1 variants.
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页码:117 / 120
页数:4
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