CDNA CLONING OF A PUTATIVE PROTOCHORADATE FK506-BINDING PROTEIN

被引：17

作者：

PANCER, Z ^{[1
]}

GERSHON, H ^{[1
]}

RINKEVICH, B ^{[1
]}

机构：

[1] TECHNION ISRAEL INST TECHNOL,BRUCE RAPPAPORT FAC MED,DEPT IMMUNOL,IL-31096 HAIFA,ISRAEL

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 197卷 / 02期

关键词：

D O I：

10.1006/bbrc.1993.2574

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A tunicate (Botryllus schlosseri) cDNA library was screened with a microsatellite probe. Five positive clones were sequenced, each with a 5′ truncated microsatellite. One (Bs.6) revealed striking similarity to FK506 and rapamycin-binding proteins (FKBPs). Clone Bs.6 is 500 base pairs long and encodes for a putative protein of 134 amino acids. The predicted protein features the two FKBP-type peptidyl-prolyl cis-trans isomerase (PPIase) signatures and an endoplasmic reticulum retention signal. This protochordate protein is substantially similar to 12-13 kDa FKBPs, most remarkably to one of the receptors that had been proposed to mediate the immunosuppressive actions of FK506, the human FKBP-13 (62% amino acid identity and 74% similarity). © 1993 Academic Press. All rights reserved.

引用

页码：973 / 977

页数：5

共 50 条

[21] Selective inhibitors of the FK506-binding protein 51 by induced fit [J].

Gaali, Steffen ;

Kirschner, Alexander ;

Cuboni, Serena ;

Hartmann, Jakob ;

Kozany, Christian ;

Balsevich, Georgia ;

Namendorf, Christian ;

Fernandez-Vizarra, Paula ;

Sippel, Claudia ;

Zannas, Anthony S. ;

Draenert, Rika ;

Binder, Elisabeth B. ;

Almeida, Osborne F. X. ;

Ruehter, Gerd ;

Uhr, Manfred ;

Schmidt, Mathias V. ;

Touma, Chadi ;

Bracher, Andreas ;

Hausch, Felix .

NATURE CHEMICAL BIOLOGY, 2015, 11 (01) :33-+

[22] In vivo regulation of human CrkII by cyclophilin A and FK506-binding protein [J].

Nath, Pulak Ranjan ;

Dong, Guangyu ;

Braiman, Alex ;

Isakov, Noah .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 470 (02) :411-416

[23] Redox sensitivity of the ryanodine receptor interaction with FK506-binding protein [J].

Zissimopoulos, Spyros ;

Docrat, Naadiya ;

Lai, F. Anthony .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (10) :6976-6983

[24] Molecular docking study of macrocycles as Fk506-binding protein inhibitors [J].

MacDonald, Corey A. ;

Boyd, Russell J. .

JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2015, 59 :117-122

[25] CLONING, OVEREXPRESSION AND PURIFICATION OF THE PREDOMINANT MAST-CELL FK506-BINDING PROTEIN FKBP-13 [J].

HULTSCH, T ;

KNOP, J ;

HOHMAN, RJ .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1994, 102 (04) :564-564

[26] CDNA-ENCODING MURINE FK506-BINDING PROTEIN (FKBP) - NUCLEOTIDE AND DEDUCED AMINO-ACID-SEQUENCES [J].

NELSON, PA ;

LIPPKE, JA ;

MURCKO, MA ;

ROSBOROUGH, SL ;

PEATTIE, DA .

GENE, 1991, 109 (02) :255-258

[27] Role of FK506-binding protein in Ca2+ spark regulation [J].

Zhao, Yan-Ting ;

Guo, Yun-Bo ;

Fan, Xue-Xin ;

Yang, Hua-Qian ;

Zhou, Peng ;

Chen, Zheng ;

Yuan, Qi ;

Ye, Haihong ;

Ji, Guang-Ju ;

Wang, Shi-Qiang .

SCIENCE BULLETIN, 2017, 62 (19) :1295-1303

[28] Propagation of conformational instability in FK506-binding protein FKBP12 [J].

LeMaster, David M. ;

Bashir, Qamar ;

Hernandez, Griselda .

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2024, 1872 (03)

[29] The FK506-binding protein, Fpr4, is an acidic histone chaperone [J].

Xiao, Haijie ;

Jackson, Vaughn ;

Lei, Ming .

FEBS LETTERS, 2006, 580 (18) :4357-4364

[30] A nuclear FK506-binding protein is a histone chaperone regulating rDNA silencing [J].

Takashi Kuzuhara ;

Masami Horikoshi .

Nature Structural & Molecular Biology, 2004, 11 :275-283

← 1 2 3 4 5 →