USE OF A PHARMACOKINETIC MODEL FOR INDIVIDUALIZING INTRAVENOUS DOSES OF AMINOPHYLLINE

A reliable method for individualizing intravenous doses of aminophylline is reported. Individual kinetic parameters, half-life (t1/2), volume of distribution (Vd), and theophylline clearance (Qb) were established for 13 patients from serum level-time data obtained after an initial intravenous load. Using a one-compartment open model predictions of serum concentrations after initiation of a constant infusion were made. Follow-up serum concentrations [32] were measured for comparison with predicted levels. A good correlation (r=0.83) was obtained. Ninety-five percent confident interval of y on x= ±2.81 μg/ml. No cases of aminophylline toxicity were observed. © 1979 Springer-Verlag.