AXONAL MICROTUBULES - THEIR REGULATION BY THE ELECTRICAL-ACTIVITY OF THE NERVE

被引：15

作者：

ALVAREZ, J

RAMIREZ, BU

机构：

[1] Laboratorio de Neurocitología, Departamento de Biologia Celular, Universidad Católica de Chile, Santiago

来源：

NEUROSCIENCE LETTERS | 1979年 / 15卷 / 01期

关键词：

D O I：

10.1016/0304-3940(79)91522-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of nerve impulses upon the axonal microtubules was studied in the sural nerve of the cat. We showed that a sustained activity (40 impulses/sec for 2 h) determines a difference in microtubule counts: the active nerve exhibited 24% more profiles than the resting one. In addition, microtubules of the active nerve appear to be less sensitive to the depolymerizing action of colchicine. We propose that the action potential leads to a decrease of the disassembly rate constant of microtubules. © 1979.

引用

页码：19 / 22

页数：4

共 13 条

[1]

DIPOLO R, 1976, J GEN PHYSIOL, V67, P433, DOI 10.1085/jgp.67.4.433

[2] REGULATORY ROLE OF DIVALENT-CATIONS IN HUMAN GRANULOCYTE CHEMOTAXIS - EVIDENCE FOR AN ASSOCIATION BETWEEN CALCIUM EXCHANGES AND MICROTUBULE ASSEMBLY [J].