CANATOXIN INDUCES ACTIVATION ON MICE PERITONEAL-MACROPHAGES

被引：0

作者：

GHAZALEH, FA ^{[1
]}

ARAUJO, CF ^{[1
]}

BARJAFIDALGO, C ^{[1
]}

CARLINI, CR ^{[1
]}

机构：

[1] UNIV ESTADO RIO DE JANEIRO,INST BIOL,DEPT FARMACOL,BR-20551-000 RIO JANEIRO,BRAZIL

来源：

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH | 1992年 / 25卷 / 10期

关键词：

MACROPHAGES; CANATOXIN; PHAGOCYTOSIS; N-ACETYL-BETA-D-GLUCOSAMINIDASE;

D O I：

暂无

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Canatoxin (CNTX), the toxic protein from Canavalia ensiformis seeds, injected into the peritoneal cavities of mice (10 mug/cavity) induced a significant neutrophil migration (10.5 +/- 0.5 x 10(6) cells/cavity) after 4 h. A later migratory effect (48 h) on mononuclear cells, predominantly macrophages, was also observed (controls: 7 +/- 0.9; CNTX: 17 +/- 2.0 x 10(6) cells/cavity). These CNTX-elicited macrophages, when compared to resident cells (R) or cells elicited by thioglycollate (TG), had an increased content of the lysosomal enzyme N-acetyl-beta-D-glucosaminidase (R: 4.5 +/- 0.5; TG: 7.2 +/- 1.0; CNTX: 20.2 +/- 3.0 mU/10(6) cells) and a greater (greater-than-or-equal-to 100%) phagocytic activity. The data suggest that CNTX-stimulated macrophages presented some characteristics of activated cells.

引用

页码：1033 / 1035

页数：3

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