INTERACTION OF FELBAMATE WITH SEVERAL OTHER ANTIEPILEPTIC DRUGS AGAINST SEIZURES INDUCED BY MAXIMAL ELECTROSHOCK IN MICE

被引：24

作者：

GORDON, R

GELS, M

WICHMANN, J

DIAMANTIS, W

SOFIA, RD

机构：

[1] Wallace Laboratories, Division of Carter-Wallace, Cranbury, New Jersey

来源：

EPILEPSIA | 1993年 / 34卷 / 02期

关键词：

ANTICONVULSANTS; FELBAMATE; MAXIMAL ELECTROSHOCK SEIZURES; PROTECTIVE INDEX; DRUG TOXICITY; DRUG INTERACTION; PHENYTOIN; VALPROATE; CARBAMAZEPINE; PHENOBARBITAL;

D O I：

10.1111/j.1528-1157.1993.tb02423.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The anticonvulsant effects of felbamate (FBM) alone or in combination with phenytoin (PHT), carbamazepine (CBZ), valproate (VPA), or phenobarbital (PB) were investigated against maximal electroshock (MES) seizures in mice. Nonprotective doses of the prototype antiepileptic drugs (AEDs) enhanced the protective effects of FBM against electrically induced seizures, as shown by significant reduction of FBM ED50 values. Toxicity as determined by rotorod test was not significantly potentiated, however, and the protective index (PI = TD50/ED50) of FBM was increased by >100% for each AED interaction, The increase in anticonvulsant potency of FBM after its combination with nonprotective doses of AEDs could not be accounted for by a pharmacokinetic mechanism.

引用

页码：367 / 371

页数：5

共 50 条

[31] Influence of MPEP (a selective mGluR5 antagonist) on the anticonvulsant action of novel antiepileptic drugs against maximal electroshock-induced seizures in mice
Zolkowska, Dorota
Kondrat-Wrobel, Maria W.
Florek-Luszczki, Magdalena
Luszczki, Jarogniew J.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2016, 65 : 172 - 178
[32] Effect of sildenafil on the anticonvulsant action of classical and second-generation antiepileptic drugs in maximal electroshock-induced seizures in mice
Nieoczym, Dorota
Luszczki, Jarogniew J.
Czuczwar, Stanislaw J.
Wlaz, Piotr
EPILEPSIA, 2010, 51 (08) : 1552 - 1559
[33] Raloxifene potentiates the effect of fluoxetine against maximal electroshock induced seizures in mice
Pottoo, Faheem Hyder
Tabassum, Nahida
Javed, Md Noushad
Nigar, Shah
Sharma, Shrestha
Abul Barkat, Md
Harshita
Alam, Md Sabir
Ansari, Mohammad Azam
Barreto, George E.
Ashraf, Ghulam Md
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2020, 146
[34] MAXIMAL AUDIOGENIC AND ELECTROSHOCK SEIZURES IN MICE AND THEIR ALTERATION BY PSYCHOPHARMACOLOGIC DRUGS
SWINYARD, EA
FINK, GB
FEDERATION PROCEEDINGS, 1959, 18 (01) : 449 - 449
[35] MODIFICATION OF MAXIMAL AUDIOGENIC AND ELECTROSHOCK SEIZURES IN MICE BY PSYCHOPHARMACOLOGIC DRUGS
FINK, GB
SWINYARD, EA
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1959, 127 (04): : 318 - 324
[36] Effect of venlafaxine on maximal electroshock induced seizures in mice
Feyza Aricioglu
Gamze Salanturoglu
Ulas Buldanlioglu
Suleyman Ozyalcin
Annals of General Psychiatry, 5 (Suppl 1)
[37] Chronic caffeine and the anticonvulsant potency of antiepileptic drugs against maximal electroshock
Gasior, M
Borowicz, K
Kleinrok, Z
Czuczwar, SJ
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1996, 54 (04) : 639 - 644
[38] Effect of acute and chronic treatment with milnacipran potentiates the anticonvulsant activity of conventional antiepileptic drugs in the maximal electroshock-induced seizures in mice
Borowicz, Kinga K.
Furmanek-Karwowska, Kamila
Morawska, Marta
Luszczki, Jarogniew J.
Czuczwar, Stanislaw J.
PSYCHOPHARMACOLOGY, 2010, 207 (04) : 661 - 669
[39] Effect of acute and chronic treatment with milnacipran potentiates the anticonvulsant activity of conventional antiepileptic drugs in the maximal electroshock-induced seizures in mice
Kinga K. Borowicz
Kamila Furmanek-Karwowska
Marta Morawska
Jarogniew J. Luszczki
Stanislaw J. Czuczwar
Psychopharmacology, 2010, 207 : 661 - 669
[40] ELECTROSHOCK SEIZURES IN THE HAMSTER AND THEIR MODIFICATION BY ANTIEPILEPTIC DRUGS
LANPHIER, EH
FEDERATION PROCEEDINGS, 1949, 8 (01) : 312 - 312

← 1 2 3 4 5 →