INTERACTION OF FELBAMATE WITH SEVERAL OTHER ANTIEPILEPTIC DRUGS AGAINST SEIZURES INDUCED BY MAXIMAL ELECTROSHOCK IN MICE

被引：24
|
作者：
GORDON, R
GELS, M
WICHMANN, J
DIAMANTIS, W
SOFIA, RD
机构：
[1] Wallace Laboratories, Division of Carter-Wallace, Cranbury, New Jersey
来源：
EPILEPSIA | 1993年 / 34卷 / 02期
关键词：
ANTICONVULSANTS; FELBAMATE; MAXIMAL ELECTROSHOCK SEIZURES; PROTECTIVE INDEX; DRUG TOXICITY; DRUG INTERACTION; PHENYTOIN; VALPROATE; CARBAMAZEPINE; PHENOBARBITAL;
D O I：
10.1111/j.1528-1157.1993.tb02423.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The anticonvulsant effects of felbamate (FBM) alone or in combination with phenytoin (PHT), carbamazepine (CBZ), valproate (VPA), or phenobarbital (PB) were investigated against maximal electroshock (MES) seizures in mice. Nonprotective doses of the prototype antiepileptic drugs (AEDs) enhanced the protective effects of FBM against electrically induced seizures, as shown by significant reduction of FBM ED50 values. Toxicity as determined by rotorod test was not significantly potentiated, however, and the protective index (PI = TD50/ED50) of FBM was increased by >100% for each AED interaction, The increase in anticonvulsant potency of FBM after its combination with nonprotective doses of AEDs could not be accounted for by a pharmacokinetic mechanism.
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页码：367 / 371
页数：5
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