Mirror symmetry of higher order aberrations between right and left eyes

Introduction: There is evidence that certain measures of visual function show some type of relationship between right and left eyes in the same individual. Similarly, particular ocular maladies may be related, or be symmetric, in the right and left eyes of the same person. There is also evidence to suggest that certain relationships do not exist between eyes in an individual. For example, diseases such as glaucoma are often asymmetric in their progression in the two eyes of an afflicted individual. Inter-ocular mirror symmetry between right and left eyes, when considering ocular wavefront aberrations (WAs), has been shown to exist by some authors. This study investigates whether mirror symmetry of high order aberrations (HOAs) exists between the right and left eyes in a cohort of South African subjects. Method: Third to 5th order Zernike coefficients HOAs) were measured on both eyes of 66 subjects (132 eyes) using a Zywave aberrometer. A total of 15 Zernike coefficients for each eye were obtained. Mirror symmetry was investigated using correlation coefficients between the various measurements obtained from each eye. Results: Pearson product-moment correlation coefficients provide evidence that the majority of the 15 Zernike coefficients suggest the presence of mirror symmetry between right and left eyes of the 66 subjects. Examples of individual scatter plots comparing right and left eyes are presented. Conclusion: The results of this study suggest that mirror symmetry exists in the HOAs obtained from the 132 eyes measured and thus care should be exercised when combining eyes of individuals for analysis.