TRANSFECTING ACTIVITY OF PHOTOIRRADIATED PHI-X 174 DNA IN THE PRESENCE OF HYDROPEROXYNAPHTHALIMIDES

被引：11

作者：

MATSUGO, S ^{[1
]}

KODAIRA, K ^{[1
]}

SAITO, I ^{[1
]}

机构：

[1] KYOTO UNIV,FAC ENGN,DEPT SYNTHET CHEM,KYOTO 606,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(00)80040-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Supercoiled double-stranded (form 1) DNA of bacteriopharge phix 174 was photoirradiated with hydroperoxynaphthalimide derivatives (1-3) and ''photo-Fenton reagent'' 4 . The lesion caused by hydroxyl radical was deleterious enough to inactivate the phix 174 DNA. The plaque formation of phix 174 DNA was analyzed after 24 h incubation, indicating a fatal effect in vivo of hydroxyl radical generated from 4.

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页码：1671 / 1674

页数：4

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