TRANSFECTING ACTIVITY OF PHOTOIRRADIATED PHI-X 174 DNA IN THE PRESENCE OF HYDROPEROXYNAPHTHALIMIDES

被引：11
作者：
MATSUGO, S [1 ]
KODAIRA, K [1 ]
SAITO, I [1 ]
机构：
[1] KYOTO UNIV,FAC ENGN,DEPT SYNTHET CHEM,KYOTO 606,JAPAN
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 08期
关键词：
D O I：
10.1016/S0960-894X(00)80040-2
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Supercoiled double-stranded (form 1) DNA of bacteriopharge phix 174 was photoirradiated with hydroperoxynaphthalimide derivatives (1-3) and ''photo-Fenton reagent'' 4 . The lesion caused by hydroxyl radical was deleterious enough to inactivate the phix 174 DNA. The plaque formation of phix 174 DNA was analyzed after 24 h incubation, indicating a fatal effect in vivo of hydroxyl radical generated from 4.
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页码：1671 / 1674
页数：4
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