CLONING OF A T-CELL GROWTH-FACTOR THAT INTERACTS WITH THE BETA-CHAIN OF THE INTERLEUKIN-2 RECEPTOR

被引：1333
作者：
GRABSTEIN, KH
EISENMAN, J
SHANEBECK, K
RAUCH, C
SRINIVASAN, S
FUNG, V
BEERS, C
RICHARDSON, J
SCHOENBORN, MA
AHDIEH, M
JOHNSON, L
ALDERSON, MR
WATSON, JD
ANDERSON, DM
GIRI, JG
机构：
[1] Immunex Research and Development Corporation, Seattle, WA 98101
来源：
SCIENCE | 1994年 / 264卷 / 5161期
关键词：
D O I：
10.1126/science.8178155
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues and shares many biological properties with IL-2. Monoclonal antibodies to the beta chain of the IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 receptor.
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收藏
页码：965 / 968
页数：4
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