CATALYTIC ENANTIOSELECTIVE CONJUGATE ADDITION OF CHIRAL ALKOXYDIMETHYLCUPRATE TO (E)-CYCLOPENTADEC-2-ENONE

被引：17

作者：

TANAKA, K ^{[1
]}

MATSUI, J ^{[1
]}

SUZUKI, H ^{[1
]}

WATANABE, A ^{[1
]}

机构：

[1] NIPPON MIN CO LTD,BIOSCI RES LABS,TODA,SAITAMA 335,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 10期

关键词：

D O I：

10.1039/p19920001193

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric 1,4-addition of methyllithium to (E)-cyclopentadec-2-enone was promoted by the chiral cuprate catalyst prepared from (1R,2R,3S,4S)-3-[(1 -methylpyrrol-2-yl)methylamino]-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol and copper(I) iodide to give (R)-(-)-muscone in 76% chemical yield and 96% enantiomeric excess.

引用

页码：1193 / 1194

页数：2

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