AMNESIA BY POST-TRAINING INFUSION OF GLUTAMATE RECEPTOR ANTAGONISTS INTO THE AMYGDALA, HIPPOCAMPUS, AND ENTORHINAL CORTEX

被引：156

作者：

JERUSALINSKY, D ^{[1
]}

FERREIRA, MBC ^{[1
]}

WALZ, R ^{[1
]}

DASILVA, RC ^{[1
]}

BIANCHIN, M ^{[1
]}

RUSCHEL, AC ^{[1
]}

ZANATTA, MS ^{[1
]}

MEDINA, JH ^{[1
]}

IZQUIERDO, I ^{[1
]}

机构：

[1] UNIV FED RIO GRANDE SUL CTR, INST BIOCIENCIAS, DEPT BIOQUIM, CTR MEMORIA, BR-90050 PORTO ALEGRE, RS, BRAZIL

来源：

BEHAVIORAL AND NEURAL BIOLOGY | 1992年 / 58卷 / 01期

关键词：

D O I：

10.1016/0163-1047(92)90982-A

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The blockers of glutamate receptors, aminophosphonovaleric acid (AP5) (5.0 μg) and ciano-nitro-quinoxalinedione (CNQX) (0.5 μg), were infused bilaterally into the amygdala, dorsal hippocampus, or entorhinal cortex of rats through indwelling cannulae 0, 90, 180, or 360 min after step-down inhibitory avoidance training. Animals were tested for retention 24 h after training. In the amygdala or hippocampus, AP5 was amnestic when given 0 min after training and CNQX was amnestic when given 0, 90, or 180 min after training. In the entorhinal cortex, AP5 was amnestic when given 90 or 180 min after training and CNQX had no effect. The results suggest that a phenomenon sensitive first to AP5 and then to CNQX in the amygdala and hippocampus, probably long-term potentiation (LTP), is crucial to post-training memory processing. LTP in these two structures could underlie their role in memory consolidation and could explain the late involvement of the entorhinal cortex in post-training memory processing. © 1978 Academic Press, Inc.

引用

页码：76 / 80

页数：5

共 10 条

[1] ONTOGENIC DEVELOPMENT OF HABIT AND MEMORY FORMATION IN PRIMATES [J].