TRANSACTIVATION OF THE TUMOR-NECROSIS-FACTOR-ALPHA PROMOTER BY THE HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I TAX1 PROTEIN

被引：43

作者：

ALBRECHT, H

SHAKHOV, AN

JONGENEEL, CV

机构：

[1] LUDWIG INST CANC RES,LAUSANNE BRANCH,CH-1066 EPALINGES,SWITZERLAND

[2] SWISS INST EXPTL CANC RES,CH-1066 EPALINGES,SWITZERLAND

来源：

JOURNAL OF VIROLOGY | 1992年 / 66卷 / 10期

关键词：

D O I：

10.1128/JVI.66.10.6191-6193.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In a cotransfection assay, the human T-cell leukemia virus type I Tax1 gene product specifically activated transcription from the mouse tumor necrosis factor alpha-promoter. The activation patterns of 5' deletion mutants, artificial enhancer constructs, and point mutations in the promoter indicate that the major Tax1-responsive element is a site at position -655 which binds the NF-kappa-B/rel and NF-GMa transcription factors.

引用

收藏

页码：6191 / 6193

页数：3

相关论文

共 25 条

[1] HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I TAX INDUCES EXPRESSION OF THE REL-RELATED FAMILY OF KAPPA-B ENHANCER-BINDING PROTEINS - EVIDENCE FOR A PRETRANSLATIONAL COMPONENT OF REGULATION [J].

ARIMA, N ;

MOLITOR, JA ;

SMITH, MR ;

KIM, JH ;

DAITOKU, Y ;

GREENE, WC .

JOURNAL OF VIROLOGY, 1991, 65 (12) :6892-6899

[2] THE BIOLOGY OF CACHECTIN/TNF - A PRIMARY MEDIATOR OF THE HOST RESPONSE [J].

BEUTLER, B ;

CERAMI, A .

ANNUAL REVIEW OF IMMUNOLOGY, 1989, 7 :625-655

[3] REGULATION OF TUMOR NECROSIS FACTOR-ALPHA TRANSCRIPTION IN MACROPHAGES - INVOLVEMENT OF 4 KAPPA-B-LIKE MOTIFS AND OF CONSTITUTIVE AND INDUCIBLE FORMS OF NF-KAPPA-B [J].

COLLART, MA ;

BAEUERLE, P ;

VASSALLI, P .

MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (04) :1498-1506

[4]

DROUET C, 1991, J IMMUNOL, V147, P1694

[5] HIV-1, HTLV-1 AND NORMAL T-CELL GROWTH - TRANSCRIPTIONAL STRATEGIES AND SURPRISES [J].

GREENE, WC ;

BOHNLEIN, E ;

BALLARD, DW .

IMMUNOLOGY TODAY, 1989, 10 (08) :272-278

[6] TUMOR NECROSIS FACTOR IDENTIFIED IN MULTIPLE-SCLEROSIS BRAIN [J].

HOFMAN, FM ;

HINTON, DR ;

JOHNSON, K ;

MERRILL, JE .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (02) :607-612

[7] INDUCTION OF INTERLEUKIN-2 RECEPTOR GENE-EXPRESSION BY P40X ENCODED BY HUMAN T-CELL LEUKEMIA-VIRUS TYPE-1 [J].

INOUE, J ;

SEIKI, M ;

TANIGUCHI, T ;

TSURU, S ;

YOSHIDA, M .

EMBO JOURNAL, 1986, 5 (11) :2883-2888

[8] MANIFESTATIONS OF HUMAN T-LYMPHOTROPIC VIRUS TYPE-I INFECTION [J].

KIM, JH ;

DURACK, DT .

AMERICAN JOURNAL OF MEDICINE, 1988, 84 (05) :919-928

[9] OVEREXPRESSION OF TRANSFORMING GROWTH-FACTOR-BETA IN TRANSGENIC MICE CARRYING THE HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-I TAX GENE [J].

KIM, SJ ;

WINOKUR, TS ;

LEE, HD ;

DANIELPOUR, D ;

KIM, KY ;

GEISER, AG ;

CHEN, LS ;

SPORN, MB ;

ROBERTS, AB ;

JAY, G .

MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (10) :5222-5228

[10] DEREGULATION OF INTERLEUKIN-2 RECEPTOR GENE-EXPRESSION IN HTLV-I-INDUCED ADULT T-CELL LEUKEMIA [J].

KRONKE, M ;

LEONARD, WJ ;

DEPPER, JM ;

GREENE, WC .

SCIENCE, 1985, 228 (4704) :1215-1217