IMIDAZOL-1-YLALKANOATE ESTERS AND THEIR CORRESPONDING ACIDS - A NOVEL SERIES OF EXTRINSIC H-1-NMR PROBES FOR INTRACELLULAR PH

被引：28

作者：

GIL, MS

CRUZ, F

CERDAN, S

BALLESTEROS, P

机构：

[1] Univ Nacl Educ Distancia, FAC CIENCIAS, DEPT QUIM ORGAN & BIOL, E-28040 MADRID, SPAIN

[2] CSIC, INST INVEST BIOMED, E-28029 MADRID, SPAIN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(00)80463-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of extrinsic probes for intracellular pH (pH(i)) determination by H-1 NMR is described. Imidazol-1-ylacetate, malonate, 3-glutarate and 2-succinate esters were synthesized by reaction of imidazole either with alpha-bromoesters or with alpha,beta-unsaturated esters. The corresponding acids were prepared by hydrolysis.

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页码：1717 / 1722

页数：6

相关论文

共 17 条

[1] 1,5-BIS-(N-BENZYL-N,N-DIETHYLAMMONIUM) DIETHYLETHER, DICHLORIDE (BBDE CL) - A NOVEL BIS-AMMONIUM SALT AS PHASE-TRANSFER CATALYST [J].

ALVAREZBUILLA, J ;

VAQUERO, JJ ;

NAVIO, JLG ;

CABELLO, JF ;

SUNKEL, C ;

DECASAJUANA, MF ;

DORREGO, F ;

SANTOS, L .

TETRAHEDRON, 1990, 46 (03) :967-978

[2] THE SEPARATION OF PHOSPHOCREATINE FROM CREATINE, AND PH DETERMINATION IN FROG-MUSCLE BY NATURAL ABUNDANCE C-13-NMR [J].

ARUS, C ;

CHANG, YC ;

BARANY, M .

BIOCHIMICA ET BIOPHYSICA ACTA, 1985, 844 (01) :91-93

[3] REACTIVITY OF AZOLES TOWARDS BENZALDEHYDE AND ITS DIMETHYLACETAL - SYNTHESIS OF N,N'-DIAZOLYLPHENYLMETHANES [J].

BALLESTEROS, P ;

ELGUERO, J ;

CLARAMUNT, RM .

TETRAHEDRON, 1985, 41 (24) :5955-5963

[4] AKTIVIERUNG N-HALTIGER HETEROCYCLEN DURCH SILYLIERUNG [J].

BIRKOFER, L ;

RICHTER, P ;

RITTER, A .

CHEMISCHE BERICHTE-RECUEIL, 1960, 93 (12) :2804-2809

[5] METABOLIC-REGULATION VIA INTRACELLULAR PH [J].

BUSA, WB ;

NUCCITELLI, R .

AMERICAN JOURNAL OF PHYSIOLOGY, 1984, 246 (04) :R409-R438

[6]

COHEN R D, 1975, Critical Reviews in Clinical Laboratory Sciences, V6, P101, DOI 10.3109/10408367509151567

[7] REGULATION OF INTRACELLULAR PH BY HUMAN PERIPHERAL-BLOOD LYMPHOCYTES AS MEASURED BY F-19 NMR [J].

DEUTSCH, C ;

TAYLOR, JS ;

WILSON, DF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (24) :7944-7948

[8]

GADIAN DG, 1982, NUCL MAGN RESON, P29

[9]

HENDERSON RM, 1988, PH HOMEOSTASIS MECHA, P5

[10] ALKYLENEIMIDES .7. A NEW SYNTHESIS OF 2,7-NAPHTHYRIDINE DERIVATIVES [J].

ISELIN, BM ;

HOFFMANN, K .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1954, 76 (12) :3220-3222