ASSAY AND STABILITY OF CHLORPROPAMIDE IN SOLID DISPERSION WITH UREA

被引：21

作者：

FORD, JL

STEWART, AF

RUBINSTEIN, MH

机构：

[1] School of Pharmacy, Liverpool Polytechnic, Liverpool, L3 3AF, Byrom Street

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1979年 / 31卷 / 11期

关键词：

D O I：

10.1111/j.2042-7158.1979.tb13645.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Thin layer chromatography followed by reflectance densitometry has been used to evaluate the stability of chlorpropamide‐urea during the fusion process. Urea was found to decompose to biuret and chlorpropamide to p‐chlorobenzenesulphonamide: several other unidentified decomposition products were detected. The energy for decomposition of chlorpropamide was 57·1 kJmol−1 for melts containing 15 and 30% chlorpropamide. Decomposition followed apparent first order kinetics. 1979 Royal Pharmaceutical Society of Great Britain

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页码：726 / 729

页数：4

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