The traditional Triple Helix innovation model focuses on university-industry-government relations. The Quadruple Helix innovation systems bring in the perspectives of the media-based and culture-based public as well as that of civil society. The Quintuple Helix emphasizes the natural environments of society, also for the knowledge production and innovation. Therefore, the quadruple helix contextualizes the triple helix, and the quintuple helix the quadruple helix. Features of the quadruple helix are: culture (cultures) and innovation culture (innovation cultures); the knowledge of culture and the culture of knowledge; values and lifestyles; multiculturalism, multiculture, and creativity; media; arts and arts universities; and multi-level innovation systems (local, national, global), with universities of the sciences, but also universities of the arts. The democracy of knowledge, as a concept and metaphor, highlights and underscores parallel processes between political pluralism in advanced democracy, and knowledge and innovation heterogeneity and diversity in advanced economy and society. The "mode 3" knowledge production system (MODE3KPS; expanding and extending the "mode 1" and "mode 2" knowledge production systems) is at the heart of the fractal research, education and innovation ecosystem. MODE3KPS universities or higher education systems are interested in integrating and combining mode 1 and mode 2. The concept of open innovation diplomacy (OID) encompasses the concept and practice of bridging distance and other divides (cultural, socioeconomic, technological, etc.) with focused and properly targeted initiatives to connect ideas and solutions with markets and investors ready to appreciate them and nurture them to their full potential. In this sense, OID qualifies as a new and novel strategy, policy-making, and governance approach in the context of the quadruple and quintuple innovation helices.
