SPATIAL DISCONTINUITIES IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 QUASI-SPECIES DERIVED FROM EPIDERMAL LANGERHANS CELLS OF A PATIENT WITH AIDS AND EVIDENCE FOR DOUBLE INFECTION

被引：55
作者：
SALA, M
ZAMBRUNO, G
VARTANIAN, JP
MARCONI, A
BERTAZZONI, U
WAINHOBSON, S
机构：
[1] INST PASTEUR,UNITE RETROVIROL MOLEC,F-75724 PARIS,FRANCE
[2] UNIV MODENA,DEPT DERMATOL,I-41100 MODENA,ITALY
[3] CNR,IST GENET BIOCHIM EVOLUZIONIST,I-27100 PAVIA,ITALY
来源：
JOURNAL OF VIROLOGY | 1994年 / 68卷 / 08期
关键词：
D O I：
10.1128/JVI.68.8.5280-5283.1994
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A nonhomogeneous spatial distribution of human immunodeficiency virus type 1 quasispecies was observed for epidermal Langerhans cells purified from skin patches taken from a patient with AIDS soon after death. Each patch presented a unique collection of sequences, distinct from those of juxtaposed patches or those derived from the other leg. Infection of Langerhans cells by virus from underlying T cells in the dermis might explain this partition. The analysis revealed the presence of two distinct cocirculating viral strains, indicating double infection.
引用
收藏
页码：5280 / 5283
页数：4
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