Progress in Understanding the Immunopathogenesis of Psoriasis

被引：85

作者：

Mak, R. K. H. ^{[1
]}

Hundhausen, C. ^{[1
]}

Nestle, F. O. ^{[1
]}

机构：

[1] Kings Coll London, Sch Med, St Johns Inst Dermatol, St John, NF, Canada

来源：

ACTAS DERMO-SIFILIOGRAFICAS | 2009年 / 100卷

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

psoriasis; immunopathogenesis; T cells; adaptive/innate immune response;

D O I：

10.1016/S0001-7310(09)73372-1

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

This review emphasizes how translation from bench research to clinical knowledge and vice versa has resulted in considerable progress in understanding the immunopathogenesis of psoriasis. First, the journey in understanding the pathogenic mechanisms behind psoriasis is described. The roles of different components of the adaptive and innate immune systems involved in driving the inflammatory response are explained. Discovery of new immune pathways i.e. the IL23/Th17 axis and its subsequent impact on the development of novel biological therapies is highlighted. Identification of potential targets warranting further research for future therapeutic development are also discussed.

引用

页码：2 / 13

页数：12

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