A NEW ELECTROPHILIC ALANINOL SYNTHON - A GENERAL-ROUTE TO OXAZOLIDINONES OF D-2-AMINO OR (R)-2-AMINO ALCOHOLS FROM L-SERINE

被引：38
作者：
SIBI, MP
RUTHERFORD, D
SHARMA, R
机构：
[1] Department of Chemistry, North Dakota State University, Fargo
来源：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 13期
关键词：
D O I：
10.1039/p19940001675
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new electrophilic alaninol synthon, (S)-4-(4'-tolylsulfonyloxymethyl) oxazolidin-2-one, derived from serine, undergoes nucleophilic displacements with Gilman cuprates and/or Grignard/CuX reagents in high yield to provide (R)-4-substituted oxazolidinones.
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页码：1675 / 1678
页数：4
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