CHANGES IN LYMPHOCYTE BETA-ADRENERGIC RECEPTORS IN DEPRESSION AND MANIA

被引：116
|
作者：
EXTEIN, I
TALLMAN, J
SMITH, CC
GOODWIN, FK
机构：
[1] Irl Extein, M.D., was formerly Clinical Associate, Clinical Psychobiology Branch, National Institute of Mental Health
来源：
PSYCHIATRY RESEARCH | 1979年 / 1卷 / 02期
关键词：
adenyl cyclase; Affective disorder; catecholamines; cyclic AMP; dihydroalprenolol; isoproterenol;
D O I：
10.1016/0165-1781(79)90061-1
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
The β-adrenergic receptors were studied in vitro in lymphocytes obtained from patients with major affective disorders and controls. Specific L-[3H]- dihydroalprenolol binding was decreased in both depressed and manic patients compared to controls and euthymic patients. Isoproterenol-stimulated, but not prostaglandin El-stimulated, cyclic adenosine-3',5'-monophosphate production was decreased in manic and depressed patients. These results suggest decreased lymphocyte β-receptor functioning in depression and mania. This decrease may be an index of changes in brain β-receptors in mania and depression, or may simply reflect homeostatic regulation of peripheral β-receptors in response to stress-induced increases in circulating catecholamines. © 1979.
引用
收藏
页码：191 / 197
页数：7
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