DIFFERENTIAL EXPRESSION OF A FAMILY OF PUTATIVE ADENYLATE GUANYLATE-CYCLASE GENES IN TRYPANOSOMA-BRUCEI

被引：71

作者：

ALEXANDRE, S ^{[1
]}

PAINDAVOINE, P ^{[1
]}

TEBABI, P ^{[1
]}

PAYS, A ^{[1
]}

HALLEUX, S ^{[1
]}

STEINERT, M ^{[1
]}

PAYS, E ^{[1
]}

机构：

[1] UNIV BRUSSELS,DEPT MOLEC BIOL,67 RUE CHEVAUX,B-1640 RHODE ST GENESE,BELGIUM

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1990年 / 43卷 / 02期

关键词：

Adenylate cyclase; Gene expression; Guanylate cyclase; Parasite life-cycle; Trypanosome;

D O I：

10.1016/0166-6851(90)90152-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The expression site for the variant surface glycoprotein (VSG) gene of Trypanosoma brucei contains several genes of unknown function (ESAGs, for expression site-associated genes). Among these, ESAG 4 shows homology to eukaryotic adenylate/guanylate cyclase genes, in the region encoding the presumptive enzyme catalytic domain. This gene belongs to a family of related sequences, and hybridizes to the genomic DNA of other trypanosomatids, such as Trypanosoma congolense, Trypanosoma vivax and Trypanosoma mega. While ESAG 4 is transcribed only in bloodstream forms by a RNA polymerase resistant to α-amanitin, at least three other members of this family are transcribed in both bloodstream and procyclic forms, by a RNA polymerase sensitive to the drug. These genes encode different putative transmembrane proteins showing high sequence conservation in the region corresponding to the adenylate/guanylate cyclase catalytic domain. © 1990.

引用

页码：279 / 288

页数：10

共 29 条

[1] PUTATIVE GENES OF A VARIANT-SPECIFIC ANTIGEN GENE-TRANSCRIPTION UNIT IN TRYPANOSOMA-BRUCEI [J].

ALEXANDRE, S ;

GUYAUX, M ;

MURPHY, NB ;

COQUELET, H ;

PAYS, A ;

STEINERT, M ;

PAYS, E .

MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (06) :2367-2378

[2] STRUCTURE AND TRANSCRIPTION OF THE ACTIN GENE OF TRYPANOSOMA-BRUCEI [J].

BENAMAR, MF ;

PAYS, A ;

TEBABI, P ;

DERO, B ;

SEEBECK, T ;

STEINERT, M ;

PAYS, E .

MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (05) :2166-2176

[3] DISCONTINUOUS TRANSCRIPTION AND ANTIGENIC VARIATION IN TRYPANOSOMES [J].

BORST, P .

ANNUAL REVIEW OF BIOCHEMISTRY, 1986, 55 :701-732

[4] RELEASE OF THE SURFACE-COAT FROM THE PLASMA-MEMBRANE OF INTACT BLOOD-STREAM FORMS OF TRYPANOSOMA-BRUCEI REQUIRES CA2+ [J].

BOWLES, DJ ;

VOORHEIS, HP .

FEBS LETTERS, 1982, 139 (01) :17-21

[5] DIFFERENTIAL ACTIVATION BY ATRIAL AND BRAIN NATRIURETIC PEPTIDES OF 2 DIFFERENT RECEPTOR GUANYLATE CYCLASES [J].

CHANG, M ;

LOWE, DG ;

LEWIS, M ;

HELLMISS, R ;

CHEN, E ;

GOEDDEL, DV .

NATURE, 1989, 341 (6237) :68-72

[6] A MEMBRANE FORM OF GUANYLATE-CYCLASE IS AN ATRIAL NATRIURETIC PEPTIDE RECEPTOR [J].

CHINKERS, M ;

GARBERS, DL ;

CHANG, MS ;

LOWE, DG ;

CHIN, HM ;

GOEDDEL, DV ;

SCHULZ, S .

NATURE, 1989, 338 (6210) :78-83

[7] THE PROTEIN-KINASE DOMAIN OF THE ANP RECEPTOR IS REQUIRED FOR SIGNALING [J].

CHINKERS, M ;

GARBERS, DL .

SCIENCE, 1989, 245 (4924) :1392-1394

[8] TRYPANOSOMA-BRUCEI - ENRICHMENT BY UV OF INTERGENIC TRANSCRIPTS FROM THE VARIABLE SURFACE GLYCOPROTEIN GENE-EXPRESSION SITE [J].

COQUELET, H ;

TEBABI, P ;

PAYS, A ;

STEINERT, M ;

PAYS, E .

MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (09) :4022-4025

[9] COORDINATE TRANSCRIPTION OF VARIANT SURFACE GLYCOPROTEIN GENES AND AN EXPRESSION SITE ASSOCIATED GENE FAMILY IN TRYPANOSOMA BRUCEI [J].

CULLY, DF ;

IP, HS ;

CROSS, GAM .

CELL, 1985, 42 (01) :173-182

[10] POST-TRANSCRIPTIONAL CONTROL OF THE DIFFERENTIAL EXPRESSION OF PHOSPHOGLYCERATE KINASE GENES IN TRYPANOSOMA-BRUCEI [J].

GIBSON, WC ;

SWINKELS, BW ;

BORST, P .

JOURNAL OF MOLECULAR BIOLOGY, 1988, 201 (02) :315-325

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