CHROMOSOMAL LOCATION OF MURINE AND HUMAN IL-1 RECEPTOR GENES

被引：76
作者：
COPELAND, NG
SILAN, CM
KINGSLEY, DM
JENKINS, NA
CANNIZZARO, LA
CROCE, CM
HUEBNER, K
SIMS, JE
机构：
[1] TEMPLE UNIV,HLTH SCI CTR,SCH MED,FELS INST CANC RES & MOLEC BIOL,PHILADELPHIA,PA 19140
[2] IMMUNEX CORP,SEATTLE,WA 98101
来源：
GENOMICS | 1991年 / 9卷 / 01期
关键词：
D O I：
10.1016/0888-7543(91)90219-5
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The gene for the type I interleukin-1 (IL-1) receptor has been mapped in both mouse and human. In the human genome, a combination of segregation analysis of rodent-human hybrid cells and chromosomal in situ hybridization has placed the gene on the long arm of chromosome 2, at band 2q12. This is near the reported map position of the loci for IL-1α and IL-1β (2q13→2q21). The murine gene has been mapped by analysis of restriction fragment length polymorphisms in interspecific backcrosses to the centromeric end of chromosome 1, in a region that is syntenic to a portion of human chromosome 2. The murine II-1r1 gene has thus been separated from the IL-1 genes, which lie on murine chromosome 2. © 1991.
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页码：44 / 50
页数：7
相关论文
共 44 条
[31]   INTERLEUKIN-1 - MORE THAN A MEDIATOR BETWEEN LEUKOCYTES [J].
MARTIN, M ;
RESCH, K .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1988, 9 (05) :171-177
[32]  
MATSUSHIMA K, 1986, J IMMUNOL, V136, P4496
[33]   A GLUTAMINASE (GLS) GENE MAPS TO MOUSE CHROMOSOME-1, RAT CHROMOSOME-9, AND HUMAN CHROMOSOME-2 [J].
MOCK, B ;
KOZAK, C ;
SELDIN, MF ;
RUFF, N ;
DHOOSTELAERE, L ;
SZPIRER, C ;
SEUANEZ, H ;
OBRIEN, S ;
BANNER, C .
GENOMICS, 1989, 5 (02) :291-297
[34]   Chromosomal Localization of the Human Interleukin 1 alpha (IL-1 alpha) Gene [J].
Modi, William S. ;
Masuda, Akinori ;
Yamada, Masaaki ;
Oppenheim, Joost J. ;
Matsushima, Kouji ;
O'Brien, Stephen J. .
GENOMICS, 1988, 2 (04) :310-314
[35]   MAPS OF LINKAGE AND SYNTENY HOMOLOGIES BETWEEN MOUSE AND MAN [J].
NADEAU, JH .
TRENDS IN GENETICS, 1989, 5 (03) :82-86
[36]   MOLECULAR ANALYSIS OF MBCL-2 - STRUCTURE AND EXPRESSION OF THE MURINE GENE HOMOLOGOUS TO THE HUMAN-GENE INVOLVED IN FOLLICULAR LYMPHOMA [J].
NEGRINI, M ;
SILINI, E ;
KOZAK, C ;
TSUJIMOTO, Y ;
CROCE, CM .
CELL, 1987, 49 (04) :455-463
[37]   THERE IS MORE THAN ONE INTERLEUKIN-1 [J].
OPPENHEIM, JJ ;
KOVACS, EJ ;
MATSUSHIMA, K ;
DURUM, SK .
IMMUNOLOGY TODAY, 1986, 7 (02) :45-56
[38]   ASSIGNMENT OF CSF-1 TO 5Q33.1 - EVIDENCE FOR CLUSTERING OF GENES REGULATING HEMATOPOIESIS AND FOR THEIR INVOLVEMENT IN THE DELETION OF THE LONG ARM OF CHROMOSOME-5 IN MYELOID DISORDERS [J].
PETTENATI, MJ ;
LEBEAU, MM ;
LEMONS, RS ;
SHIMA, EA ;
KAWASAKI, ES ;
LARSON, RA ;
SHERR, CJ ;
DIAZ, MO ;
ROWLEY, JD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (09) :2970-2974
[39]   TANDEM LINKAGE OF HUMAN CSF-1 RECEPTOR (C-FMS) AND PDGF RECEPTOR GENES [J].
ROBERTS, WM ;
LOOK, AT ;
ROUSSEL, MF ;
SHERR, CJ .
CELL, 1988, 55 (04) :655-661
[40]   CLONING THE INTERLEUKIN-1 RECEPTOR FROM HUMAN T-CELLS [J].
SIMS, JE ;
ACRES, RB ;
GRUBIN, CE ;
MCMAHAN, CJ ;
WIGNALL, JM ;
MARCH, CJ ;
DOWER, SK .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (22) :8946-8950
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