CHROMOSOMAL LOCATION OF MURINE AND HUMAN IL-1 RECEPTOR GENES

被引：76
作者：
COPELAND, NG
SILAN, CM
KINGSLEY, DM
JENKINS, NA
CANNIZZARO, LA
CROCE, CM
HUEBNER, K
SIMS, JE
机构：
[1] TEMPLE UNIV,HLTH SCI CTR,SCH MED,FELS INST CANC RES & MOLEC BIOL,PHILADELPHIA,PA 19140
[2] IMMUNEX CORP,SEATTLE,WA 98101
来源：
GENOMICS | 1991年 / 9卷 / 01期
关键词：
D O I：
10.1016/0888-7543(91)90219-5
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The gene for the type I interleukin-1 (IL-1) receptor has been mapped in both mouse and human. In the human genome, a combination of segregation analysis of rodent-human hybrid cells and chromosomal in situ hybridization has placed the gene on the long arm of chromosome 2, at band 2q12. This is near the reported map position of the loci for IL-1α and IL-1β (2q13→2q21). The murine gene has been mapped by analysis of restriction fragment length polymorphisms in interspecific backcrosses to the centromeric end of chromosome 1, in a region that is syntenic to a portion of human chromosome 2. The murine II-1r1 gene has thus been separated from the IL-1 genes, which lie on murine chromosome 2. © 1991.
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页码：44 / 50
页数：7
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