LATENT INFECTIONS OF SENSORY GANGLIA AS INFLUENCED BY PHOSPHONOFORMATE TREATMENT OF HERPES-SIMPLEX VIRUS-INDUCED SKIN INFECTIONS IN HAIRLESS MICE

被引：15

作者：

KLEIN, RJ ^{[1
]}

DESTEFANO, E ^{[1
]}

BRADY, E ^{[1
]}

FRIEDMANKIEN, AE ^{[1
]}

机构：

[1] NYU, SCH MED, DEPT DERMATOL, NEW YORK, NY 10016 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1979年 / 16卷 / 03期

关键词：

D O I：

10.1128/AAC.16.3.266

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Topical treatment with 3% phosphonoformate of herpes simplex virus type 1 (HSV)-induced skin infections of hairless mice reduced the severity of skin lesions when the treatment was initiated 3 hr after virus inoculation in the lumbosacral area or 3 and 24 hr after inoculation in the orofacial area. The mortality was significantly reduced in lumbosacral-infected mice and was completely prevented in orofacial-infected mice when the treatment was initiated with a delay of 24 hr after virus inoculation. However, phosphonoformate did not prevent the establishment of latent herpes simplex virus type 1 infections in the spinal and trigeminal ganglia, even when treatment was initiated as early as 3 hr after infection.

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页码：266 / 270

页数：5

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