THIAZIDE-INDUCED PARATHYROID STIMULATION

被引：71
作者：
PICKLEMAN, JR
STRAUS, FH
FORLAND, M
PALOYAN, E
机构：
[1] Department of Surgery, The University of Chicago Pritzker School of Medicine, Chicago, IL
[2] Department of Medicine and Pathology, The University of Chicago Pritzker School of Medicine, Chicago, IL
[3] The Argonne Cancer Research Hospital, The University of Chicago Pritzker School of Medicine, Chicago, IL
来源：
METABOLISM | 1969年 / 18卷 / 10期
关键词：
D O I：
10.1016/0026-0495(69)90062-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Twenty dogs were given oral hydrochlorothiazide in varying dosages for periods ranging up to nine months. All dogs showed significant hypercalcemia and hypophosphatemia. In addition, the parathyroid glands of these dogs were enlarged, and many showed areas of histological changes suggestive of hyperactivity. None of these biochemical or morphological alterations were noted in twenty control dogs receiving no thiazides. It is concluded that the thiazide diuretics may cause parathyroid stimulation, and administration of these drugs should be considered in the differential diagnosis of hypercalcemia. © 1969.
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页码：867 / +
页数：1
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