THIAZIDE-INDUCED PARATHYROID STIMULATION

被引：71
作者：
PICKLEMAN, JR
STRAUS, FH
FORLAND, M
PALOYAN, E
机构：
[1] Department of Surgery, The University of Chicago Pritzker School of Medicine, Chicago, IL
[2] Department of Medicine and Pathology, The University of Chicago Pritzker School of Medicine, Chicago, IL
[3] The Argonne Cancer Research Hospital, The University of Chicago Pritzker School of Medicine, Chicago, IL
来源：
METABOLISM | 1969年 / 18卷 / 10期
关键词：
D O I：
10.1016/0026-0495(69)90062-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Twenty dogs were given oral hydrochlorothiazide in varying dosages for periods ranging up to nine months. All dogs showed significant hypercalcemia and hypophosphatemia. In addition, the parathyroid glands of these dogs were enlarged, and many showed areas of histological changes suggestive of hyperactivity. None of these biochemical or morphological alterations were noted in twenty control dogs receiving no thiazides. It is concluded that the thiazide diuretics may cause parathyroid stimulation, and administration of these drugs should be considered in the differential diagnosis of hypercalcemia. © 1969.
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页码：867 / +
页数：1
相关论文
共 24 条
[1]   HYPERPARATHYROIDISM - DIAGNOSIS AND MANAGEMENT [J].
COPE, O .
AMERICAN JOURNAL OF SURGERY, 1960, 99 (04) :394-403
[2]   CALCIUM PHOSPHORUS AND URIC ACID CLEARANCES AFTER INTRAVENOUS ADMINISTRATION OF CHLOROTHIAZIDE [J].
DUARTE, CG ;
BLAND, JH .
METABOLISM, 1965, 14 (3P1) :211-+
[3]   CHANGES IN METABOLISM OF CALCIUM PHOSPHORUS AND URIC ACID AFTER ORAL ADMINISTRATION OF CHLOROTHIAZIDE [J].
DUARTE, CG ;
BLAND, JH .
METABOLISM, 1965, 14 (08) :899-&
[4]   EFFECTS OF CHLOROTHIAZIDE AND AMIPRAMIZIDE (MK 870) ON RENAL EXCRETION OF CALCIUM PHOSPHATE AND MAGNESIUM [J].
DUARTE, CG .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1968, 17 (05) :420-&
[5]   PRIMARY HYPERPARATHYROIDISM - OBSERVATIONS IN A SERIES OF 50 CASES [J].
HELLSTROM, J .
ACTA ENDOCRINOLOGICA, 1954, 16 (01) :30-58
[6]  
KLEEMAN CR, 1964, P SOC EXP BIOL MED, V115, P29, DOI 10.3181/00379727-115-28821
[7]  
KLEEMAN CR, 1958, J CLIN INVEST, V37, P907
[8]   PARATHYROID ADENOMA - PROBLEMS IN DIAGNOSIS AND MANAGEMENT [J].
KREMENTZ, ET ;
RACE, JL ;
STERNBERG, WH ;
HAWLEY, WD .
ANNALS OF SURGERY, 1967, 165 (05) :681-+
[9]   EFFECT OF CHLOROTHIAZIDE AND HYDROCHLOROTHIAZIDE ON THE EXCRETION OF CALCIUM IN URINE [J].
LAMBERG, BA ;
KUHLBACK, B .
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 1959, 11 (04) :351-357
[10]   CALCIUM INTOXICATION DUE TO PRIMARY HYPERPARATHYROIDISM - MEDICAL + SURGICAL EMERGENCY [J].
LEMANN, J ;
DONATELLI, AA .
ANNALS OF INTERNAL MEDICINE, 1964, 60 (03) :447-+
123