IL-10 IMMUNOSUPPRESSION IN TRANSPLANTATION

被引：71
作者：
BROMBERG, JS
机构：
来源：
CURRENT OPINION IN IMMUNOLOGY | 1995年 / 7卷 / 05期
关键词：
D O I：
10.1016/0952-7915(95)80070-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The description of IL-10 as an immunosuppressive cytokine that inhibits numerous T-cell and antigen-presenting cell functions has led to the investigation of the role of IL-10 in graft acceptance and rejection, in both manipulated and unmanipulated experimental systems. Recent results suggest a complex interaction of IL-10 with other cytokines and numerous cell types. Although IL-10 is not a simple immunosuppressive molecule, manipulation of its actions may be a useful approach for prolonging graft survival and preventing rejection.
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页码：639 / 643
页数：5
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