CRYSTAL AND SOLUTION STRUCTURES OF THE OLIGONUCLEOTIDE D(ATGCGCAT)2 - A COMBINED X-RAY AND NMR-STUDY

被引：34

作者：

CLARK, GR

BROWN, DG

SANDERSON, MR

CHWALINSKI, T

NEIDLE, S

VEAL, JM

JONES, RL

WILSON, WD

ZON, G

GARMAN, E

STUART, DI

机构：

[1] INST CANC RES,CANC RES CAMPAIGN,BIOMOLEC STRUCT UNIT,SUTTON SM2 5NG,SURREY,ENGLAND

[2] GEORGIA STATE UNIV,DEPT CHEM,ATLANTA,GA 30303

[3] APPL BIOSYST INC,FOSTER CITY,CA 94404

[4] UNIV OXFORD,MOLEC BIOPHYS LAB,OXFORD OX1 5QQ,ENGLAND

来源：

NUCLEIC ACIDS RESEARCH | 1990年 / 18卷 / 18期

关键词：

D O I：

10.1093/nar/18.18.5521

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A combined crystal-structure determination and NMR analysis of the octanucleotide d(ATGCGCAT)2 is reported. The X-ray analysis shows that the structure is A-form duplex in crystal state. The NMR study shows that in solution this sequence is B-type. The conformational results from each technique are presented in detail. The implications of these findings in terms of conformational flexibility and ligand binding are discussed. © 1990 Oxford University Press.

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页码：5521 / 5528

页数：8

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