STRUCTURES OF 2 7-MEMBERED RING PYRIMIDINE NUCLEOSIDE DERIVATIVES

被引：2

作者：

SUTTON, PA

CODY, V

MARQUEZ, VE

机构：

[1] MED FDN BUFFALO, 73 HIGH ST, BUFFALO, NY 14203 USA

[2] NCI, LPET, BETHESDA, MD 20205 USA

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1987年 / 6卷 / 03期

关键词：

D O I：

10.1080/07328318708069990

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Crystal structure analyses of 1-(2,3,5-tri-0-benzoyl-.beta.-D-ribofuranosyl)-tetrahydro-2H-1,3-diazepine-2,4(3H)-dione (I) and 1-(2,3,5-tri-0-benzoyl-.beta.-D-ribofuranosyl)-6,7-dihydro-2H-1,3-diazepine-2(3H)-one (II) show that the major conformational differences between them lie in the aglycone moiety. In I the aglycone is twisted with C(6) and C(7) above, and C(5) below, the plane of the ring. In II the aglycone has a sofa conformation with C(7) above the plane of the ring. The ribose conformation in both compounds is C(1'')-exo-C(2'')-endo (2T1), the C(4'')-C(5'') orientation is gauche-gauche, and the glycoside linkage is high-anti (X = -104.5(3).degree. I, -95.2(5.degree.) II, respectively).

引用

页码：613 / 620

页数：8

共 11 条

[1]

[Anonymous], 1974, INT TABLES XRAY CRYS, VIV

[2]

ASHLEY GW, 1984, J BIOL CHEM, V259, P3615

[3] STUDIES OF ENZYMATIC DEAMINATION OF CYTOSINE ARABINOSIDE .1. ENZYME DISTRIBUTION AND SPECIES SPECIFICITY [J].