MEVINOLIN - A HIGHLY POTENT COMPETITIVE INHIBITOR OF HYDROXYMETHYLGLUTARYL-COENZYME-A REDUCTASE AND A CHOLESTEROL-LOWERING AGENT

被引：1557

作者：

ALBERTS, AW

CHEN, J

KURON, G

HUNT, V

HUFF, J

HOFFMAN, C

ROTHROCK, J

LOPEZ, M

JOSHUA, H

HARRIS, E

PATCHETT, A

MONAGHAN, R

CURRIE, S

STAPLEY, E

ALBERSSCHONBERG, G

HENSENS, O

HIRSHFIELD, J

HOOGSTEEN, K

LIESCH, J

SPRINGER, J

机构：

[1] MERCK SHARP & DOHME,DEPT NEW LEADS DISCOVERY,RAHWAY,NJ 07065

[2] MERCK SHARP & DOHME,DEPT BASIC & APPL MICROBIOL,RAHWAY,NJ 07065

[3] MERCK SHARP & DOHME,DEPT BIOPHYS,RAHWAY,NJ 07065

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES | 1980年 / 77卷 / 07期

关键词：

D O I：

10.1073/pnas.77.7.3957

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：3957 / 3961

页数：5

共 27 条

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[8]

DOI O, 1978, JPN J MED SCI BIOL, V31, P225, DOI 10.7883/yoken1952.31.225

[9] COMPETITIVE INHIBITION OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE BY ML-236A AND ML-236B FUNGAL METABOLITES, HAVING HYPOCHOLESTEROLEMIC ACTIVITY [J].

ENDO, A ;

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[10] MONACOLIN-K, A NEW HYPOCHOLESTEROLEMIC AGENT PRODUCED BY A MONASCUS SPECIES [J].

ENDO, A .

JOURNAL OF ANTIBIOTICS, 1979, 32 (08) :852-854

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