REPLACEMENT OF H2O BY D2O IN CAPILLARY ZONE ELECTROPHORESIS CAN INCREASE RESOLUTION OF PEPTIDES AND PROTEINS

被引：4

作者：

CAMILLERI, P

OKAFO, GN

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 03期

关键词：

D O I：

10.1039/c39910000196

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Water (H2O) based buffer solutions are generally used in capillary zone electrophoresis (CZE) for the separation of peptides and proteins; the replacement of H2O by D2O in the supporting electrolyte (pH, pD ca. 7.8) contributes to the suppression of electroosmotic flow, mainly due to the higher viscosity of D2O and can result in enhanced resolution of substrates without the use of additives.

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页码：196 / 198

页数：3

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